Gastrointestinal Cancers with Consideration of DPD and UGT1A1 Plasma Levels: Chemotherapy-Related Toxicity

Gastrointestinal Cancers with Consideration of DPD and UGT1A1 Plasma Levels: Chemotherapy-Related Toxicity

Unpredictable, dose-limiting toxicity remains a challenge in cancer treatment. We evaluated dihydropyrimidine dehydrogenase (DPD) and UDP-glucuronosyltransferase 1A1 (UGT1A1) plasma levels in the context of chemotherapy-induced toxicity and disease progression. Seventy gastrointestinal cancer patien...

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Main Authors: Velko Minchev, Hristo Tsankov, Bozil Robev, Martin Takov, Stefan Federchev, Kalina Kamenova, Lozan Todorov, Liliya Atanasova, Nadya Hristova-Avakumova, Rumen Nikolov, Pavlina Gateva, Vanyo Mitev
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Life
Subjects:
gastrointestinal malignancies
FOLFOX
FOLFIRI
dihydropyrimidine dehydrogenase
UDP-glucuronosyltransferase
myelotoxicity
Online Access:https://www.mdpi.com/2075-1729/15/7/1071
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https://www.mdpi.com/2075-1729/15/7/1071

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