Prediction of Monoclonal Antibody Pharmacokinetics in Pediatric Populations Using PBPK Modeling and Simulation

Prediction of Monoclonal Antibody Pharmacokinetics in Pediatric Populations Using PBPK Modeling and Simulation

<b>Background</b>: Accurately determining pediatric dosing is essential prior to initiating clinical trials or administering medications in routine clinical settings. In children, ethical considerations demand careful evaluation of both safety and effectiveness. Typically, dosing recomme...

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Bibliographic Details
Main Authors: Chiara Zunino, Virginie Gualano, Haiying Zhou, Viera Lukacova, Maxime Le Merdy
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceutics
Subjects:
PBPK
monoclonal antibody
translation
pediatrics
Online Access:https://www.mdpi.com/1999-4923/17/7/884
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