The Effects of Leptin Hormone Concentrations and Some Immunological and Biochemical Parameters in Alloxan Induced Diabetic Male Rabbits and Diabetic Treated with Alpha Lipoic Acid and L-Carnitine
This study was designed in order to estimate the effect of alloxan induced diabetes mellitus on leptin concentration and some immunological and biochemical parameters of male domestic rabbits. The study involved (20) blood samples which divided into 4 groups : group one : adult normal healthy male...
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Tikrit University
2023-01-01
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| Series: | Tikrit Journal of Pure Science |
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| Online Access: | https://tjpsj.org/index.php/tjps/article/view/621 |
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| author | Mohanad Hasan Mahmood Humadi Zaid Mohamad Mubarak Ismat Jamal Jamil |
| author_facet | Mohanad Hasan Mahmood Humadi Zaid Mohamad Mubarak Ismat Jamal Jamil |
| author_sort | Mohanad Hasan Mahmood Humadi |
| collection | DOAJ |
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This study was designed in order to estimate the effect of alloxan induced diabetes mellitus on leptin concentration and some immunological and biochemical parameters of male domestic rabbits. The study involved (20) blood samples which divided into 4 groups : group one : adult normal healthy male rabbits as control group , group two: adult male rabbits with alloxan induced diabetes mellitus, group three: adult male rabbits with alloxan induced diabetes mellitus treated with alpha lipoic acid (100 mg/kg) , group four: adult male rabbits with alloxan induced diabetes mellitus treated with L-carnitine (100 mg/kg).The results of this study showed a significant increase in leptin concentrations (P≤ 0.05) of second group in comparison with control group; while significant decrease in leptin concentrations at levels (P≤ 0.05) of third and fourth groups compared with diabetic group, and there is significant increase in proinflammatory cytokine Interleukin 6 (IL-6) concentrations (P≤ 0.05) of second group in comparison with control group, There was a significant decrease in IL-6 concentrations (P≤ 0.05) of third and fourth groups in comparison with diabetic group; also there is a significant increases in both urea and creatinine concentrations (P≤ 0.05) of second group in comparison with control group, while significant decreases in both urea and creatinine concentrations (P≤ 0.05) of third and fourth groups in comparison with diabetic group.
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| format | Article |
| id | doaj-art-4b26c76924f24c67b51a781e14bdaeb7 |
| institution | Matheson Library |
| issn | 1813-1662 2415-1726 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Tikrit University |
| record_format | Article |
| series | Tikrit Journal of Pure Science |
| spelling | doaj-art-4b26c76924f24c67b51a781e14bdaeb72025-07-12T07:23:00ZengTikrit UniversityTikrit Journal of Pure Science1813-16622415-17262023-01-0122210.25130/tjps.v22i2.621The Effects of Leptin Hormone Concentrations and Some Immunological and Biochemical Parameters in Alloxan Induced Diabetic Male Rabbits and Diabetic Treated with Alpha Lipoic Acid and L-CarnitineMohanad Hasan Mahmood HumadiZaid Mohamad MubarakIsmat Jamal Jamil This study was designed in order to estimate the effect of alloxan induced diabetes mellitus on leptin concentration and some immunological and biochemical parameters of male domestic rabbits. The study involved (20) blood samples which divided into 4 groups : group one : adult normal healthy male rabbits as control group , group two: adult male rabbits with alloxan induced diabetes mellitus, group three: adult male rabbits with alloxan induced diabetes mellitus treated with alpha lipoic acid (100 mg/kg) , group four: adult male rabbits with alloxan induced diabetes mellitus treated with L-carnitine (100 mg/kg).The results of this study showed a significant increase in leptin concentrations (P≤ 0.05) of second group in comparison with control group; while significant decrease in leptin concentrations at levels (P≤ 0.05) of third and fourth groups compared with diabetic group, and there is significant increase in proinflammatory cytokine Interleukin 6 (IL-6) concentrations (P≤ 0.05) of second group in comparison with control group, There was a significant decrease in IL-6 concentrations (P≤ 0.05) of third and fourth groups in comparison with diabetic group; also there is a significant increases in both urea and creatinine concentrations (P≤ 0.05) of second group in comparison with control group, while significant decreases in both urea and creatinine concentrations (P≤ 0.05) of third and fourth groups in comparison with diabetic group. https://tjpsj.org/index.php/tjps/article/view/621Diabetes mellitusAlloxanLeptinIL-6UreaCreatinine |
| spellingShingle | Mohanad Hasan Mahmood Humadi Zaid Mohamad Mubarak Ismat Jamal Jamil The Effects of Leptin Hormone Concentrations and Some Immunological and Biochemical Parameters in Alloxan Induced Diabetic Male Rabbits and Diabetic Treated with Alpha Lipoic Acid and L-Carnitine Tikrit Journal of Pure Science Diabetes mellitus Alloxan Leptin IL-6 Urea Creatinine |
| title | The Effects of Leptin Hormone Concentrations and Some Immunological and Biochemical Parameters in Alloxan Induced Diabetic Male Rabbits and Diabetic Treated with Alpha Lipoic Acid and L-Carnitine |
| title_full | The Effects of Leptin Hormone Concentrations and Some Immunological and Biochemical Parameters in Alloxan Induced Diabetic Male Rabbits and Diabetic Treated with Alpha Lipoic Acid and L-Carnitine |
| title_fullStr | The Effects of Leptin Hormone Concentrations and Some Immunological and Biochemical Parameters in Alloxan Induced Diabetic Male Rabbits and Diabetic Treated with Alpha Lipoic Acid and L-Carnitine |
| title_full_unstemmed | The Effects of Leptin Hormone Concentrations and Some Immunological and Biochemical Parameters in Alloxan Induced Diabetic Male Rabbits and Diabetic Treated with Alpha Lipoic Acid and L-Carnitine |
| title_short | The Effects of Leptin Hormone Concentrations and Some Immunological and Biochemical Parameters in Alloxan Induced Diabetic Male Rabbits and Diabetic Treated with Alpha Lipoic Acid and L-Carnitine |
| title_sort | effects of leptin hormone concentrations and some immunological and biochemical parameters in alloxan induced diabetic male rabbits and diabetic treated with alpha lipoic acid and l carnitine |
| topic | Diabetes mellitus Alloxan Leptin IL-6 Urea Creatinine |
| url | https://tjpsj.org/index.php/tjps/article/view/621 |
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