Metal-Induced Genotoxic Events: Possible Distinction Between Sporadic and Familial ALS

Metal-Induced Genotoxic Events: Possible Distinction Between Sporadic and Familial ALS

Metal exposure is a potential risk factor for amyotrophic lateral sclerosis (ALS). Increasing evidence suggests that elevated levels of DNA damage are present in both familial (fALS) and sporadic (sALS) forms of ALS, characterized by the selective loss of motor neurons in the brain, brainstem, and s...

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Bibliographic Details
Main Authors: William Wu Kim, Gregory Zarus, Breanna Alman, Patricia Ruiz, Moon Han, Paul Mehta, Chao Ji, Hoormat Qureshi, James Antonini, Mohammad Shoeb
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Toxics
Subjects:
ALS
biomarkers
metals
telomere
DNA damage
neurotoxicity
Online Access:https://www.mdpi.com/2305-6304/13/6/493
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