Emerging pharmaceutically active drugs: synthesis and pharmacology of Schiff base ligands with their metal complexes
Abstract Schiff bases (SBs) are biologically favored platforms with outstanding pharmaceutical importance due to fabrication of ligands and stable metal complexes in both organic and inorganic chemistry. These compounds have depicted anticancer, antitumor, antiviral, DNA binding, antioxidant, antiba...
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| Format: | Article |
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Springer
2025-06-01
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| Series: | Discover Chemistry |
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| Online Access: | https://doi.org/10.1007/s44371-025-00228-6 |
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| author | Ekhlass Uddin Md. Nazmul Sardar Md. Shahin Reza Md. Sohag Hasan Md. Tanvir Talukder Md. Mahbubul Hoque Prodip Paul Mst. Shabana Khatun Md. Faruk Hossen Md. Ali Asraf Md. Kudrat-E-Zahan |
| author_facet | Ekhlass Uddin Md. Nazmul Sardar Md. Shahin Reza Md. Sohag Hasan Md. Tanvir Talukder Md. Mahbubul Hoque Prodip Paul Mst. Shabana Khatun Md. Faruk Hossen Md. Ali Asraf Md. Kudrat-E-Zahan |
| author_sort | Ekhlass Uddin |
| collection | DOAJ |
| description | Abstract Schiff bases (SBs) are biologically favored platforms with outstanding pharmaceutical importance due to fabrication of ligands and stable metal complexes in both organic and inorganic chemistry. These compounds have depicted anticancer, antitumor, antiviral, DNA binding, antioxidant, antibacterial, antifungal, and many more features. This article mainly focuses on synthesis reactions with emphasis on the preparation and efficacy values of the synthesized SB ligands and metal compounds which will help to discover new suitable SB compounds for future perspectives. Both gram-positive (S. aureus, S. pyogenes, B. anthracis, and so forth) and gram-negative (E. coli, P. aeruginosa, S. typhi, and so forth) bacteria have been shown to be susceptible to antibacterial activity. Several metal complexes have been shown to have antifungal properties against A. niger, C. albicans, A. flavus, and other fungal species. The least inhibitory concentration (IC50) for HIV, RSV, HSV, and coronavirus has been used to summarize the in vitro antiviral characteristics. Furthermore, cytotoxic effects against a number of cell lines, such as PC-3, HeLa, HepG-2, MCF-7, HEK-293, and HCT-116, have been studied. Besides, this paper resumes recent developments on SB metal substances appended special prior with Hg, Cr, Mn, Fe, Co, Ni, Cu, V, Cd, Zn, Pb, Pt, and Pd metals, focusing mostly on their inhibitory effects. This work will help scientists to quest advanced pharmacological SB active molecules, gaining inspiration from the versatile families of aldehydes and ketones. Graphical abstract |
| format | Article |
| id | doaj-art-4a8206e566194bae8889c88fd1b1e64e |
| institution | Matheson Library |
| issn | 3005-1193 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Chemistry |
| spelling | doaj-art-4a8206e566194bae8889c88fd1b1e64e2025-06-29T11:16:24ZengSpringerDiscover Chemistry3005-11932025-06-012119010.1007/s44371-025-00228-6Emerging pharmaceutically active drugs: synthesis and pharmacology of Schiff base ligands with their metal complexesEkhlass Uddin0Md. Nazmul Sardar1Md. Shahin Reza2Md. Sohag Hasan3Md. Tanvir Talukder4Md. Mahbubul Hoque5Prodip Paul6Mst. Shabana Khatun7Md. Faruk Hossen8Md. Ali Asraf9Md. Kudrat-E-Zahan10Department of Chemistry, University of RajshahiDepartment of Pharmacy, University of RajshahiDepartment of Chemistry, Tennessee State UniversityDepartment of Chemistry, Jahangirnagar UniversityDepartment of Biochemistry and Molecular Biology, Jahangirnagar UniversityDepartment of Applied Chemistry and Chemical Engineering, University of DhakaDepartment of Microbiology, Bangladesh Agricultural UniversityDepartment of Chemistry, University of RajshahiDepartment of Chemistry, Rajshahi UniversityDepartment of Chemistry, Rajshahi UniversityDepartment of Chemistry, Rajshahi UniversityAbstract Schiff bases (SBs) are biologically favored platforms with outstanding pharmaceutical importance due to fabrication of ligands and stable metal complexes in both organic and inorganic chemistry. These compounds have depicted anticancer, antitumor, antiviral, DNA binding, antioxidant, antibacterial, antifungal, and many more features. This article mainly focuses on synthesis reactions with emphasis on the preparation and efficacy values of the synthesized SB ligands and metal compounds which will help to discover new suitable SB compounds for future perspectives. Both gram-positive (S. aureus, S. pyogenes, B. anthracis, and so forth) and gram-negative (E. coli, P. aeruginosa, S. typhi, and so forth) bacteria have been shown to be susceptible to antibacterial activity. Several metal complexes have been shown to have antifungal properties against A. niger, C. albicans, A. flavus, and other fungal species. The least inhibitory concentration (IC50) for HIV, RSV, HSV, and coronavirus has been used to summarize the in vitro antiviral characteristics. Furthermore, cytotoxic effects against a number of cell lines, such as PC-3, HeLa, HepG-2, MCF-7, HEK-293, and HCT-116, have been studied. Besides, this paper resumes recent developments on SB metal substances appended special prior with Hg, Cr, Mn, Fe, Co, Ni, Cu, V, Cd, Zn, Pb, Pt, and Pd metals, focusing mostly on their inhibitory effects. This work will help scientists to quest advanced pharmacological SB active molecules, gaining inspiration from the versatile families of aldehydes and ketones. Graphical abstracthttps://doi.org/10.1007/s44371-025-00228-6AnticancerAntitumorAntiviralDNA bindingAntioxidantAntibacterial |
| spellingShingle | Ekhlass Uddin Md. Nazmul Sardar Md. Shahin Reza Md. Sohag Hasan Md. Tanvir Talukder Md. Mahbubul Hoque Prodip Paul Mst. Shabana Khatun Md. Faruk Hossen Md. Ali Asraf Md. Kudrat-E-Zahan Emerging pharmaceutically active drugs: synthesis and pharmacology of Schiff base ligands with their metal complexes Discover Chemistry Anticancer Antitumor Antiviral DNA binding Antioxidant Antibacterial |
| title | Emerging pharmaceutically active drugs: synthesis and pharmacology of Schiff base ligands with their metal complexes |
| title_full | Emerging pharmaceutically active drugs: synthesis and pharmacology of Schiff base ligands with their metal complexes |
| title_fullStr | Emerging pharmaceutically active drugs: synthesis and pharmacology of Schiff base ligands with their metal complexes |
| title_full_unstemmed | Emerging pharmaceutically active drugs: synthesis and pharmacology of Schiff base ligands with their metal complexes |
| title_short | Emerging pharmaceutically active drugs: synthesis and pharmacology of Schiff base ligands with their metal complexes |
| title_sort | emerging pharmaceutically active drugs synthesis and pharmacology of schiff base ligands with their metal complexes |
| topic | Anticancer Antitumor Antiviral DNA binding Antioxidant Antibacterial |
| url | https://doi.org/10.1007/s44371-025-00228-6 |
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