Higher prevalence of hypervirulent Klebsiella pneumoniae isolates with high-risk multidrug resistance in Asia
Background: The emergence of hypervirulent and antibiotic-resistant Klebsiella pneumoniae isolates poses a significant global public health threat, necessitating stringent prevention and control strategies on an international scale. However, current research efforts are often geographically restrict...
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Elsevier
2025-09-01
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| Series: | Journal of Infection and Public Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034125001832 |
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| author | Lin Gan Pan Mao Ziyan Tian Xin Li Zihui Yu Bing Du Guanhua Xue Chao Yan Jinghua Cui Hanqing Zhao Yanling Feng Junxia Feng Zheng Fan Tongtong Fu Ziying Xu Yang Yang Lijuan Huang Shuo Zhao Jing Yuan |
| author_facet | Lin Gan Pan Mao Ziyan Tian Xin Li Zihui Yu Bing Du Guanhua Xue Chao Yan Jinghua Cui Hanqing Zhao Yanling Feng Junxia Feng Zheng Fan Tongtong Fu Ziying Xu Yang Yang Lijuan Huang Shuo Zhao Jing Yuan |
| author_sort | Lin Gan |
| collection | DOAJ |
| description | Background: The emergence of hypervirulent and antibiotic-resistant Klebsiella pneumoniae isolates poses a significant global public health threat, necessitating stringent prevention and control strategies on an international scale. However, current research efforts are often geographically restricted and lack integration of large-scale data analyses, limiting the understanding of the global prevalence and molecular epidemiology of K. pneumoniae. Furthermore, studies on hypervirulent K. pneumoniae (hvKp) have predominantly emphasized virulence traits, with limited exploration of their associations with molecular subtypes, such as sequence types (STs) and capsule types. Methods: To address these gaps, a total of 55,684K. pneumoniae isolates collected across global regions, were applied in this study to investigate virulence factors, antimicrobial resistance profiles, molecular typing characteristics and the intrinsic connections between these features. Results: Through the application of big data analytics, we generated a comprehensive global distribution map of K. pneumoniae, revealing a higher prevalence of hvKp isolates with high-risk multidrug resistance in Asia. Notably, sequence types ST23, ST65, and ST86 exhibited the highest proportions of hvKp isolates. Regional differences in the virulence potential of specific sequence types were associated with the presence of aerobactin, a key siderophore. Additionally, capsular type KL64 was identified as potentially correlated with hypervirulence. Conclusions: This large-scale genomic surveillance offers critical insights into the global distribution and molecular epidemiology of K. pneumoniae, providing an evidence base for risk mapping and the formulation of tailored control strategies to mitigate the threat posed by this pathogen. |
| format | Article |
| id | doaj-art-4a7cf54c0d8147948a951b51c8cbe627 |
| institution | Matheson Library |
| issn | 1876-0341 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj-art-4a7cf54c0d8147948a951b51c8cbe6272025-08-03T04:42:30ZengElsevierJournal of Infection and Public Health1876-03412025-09-01189102834Higher prevalence of hypervirulent Klebsiella pneumoniae isolates with high-risk multidrug resistance in AsiaLin Gan0Pan Mao1Ziyan Tian2Xin Li3Zihui Yu4Bing Du5Guanhua Xue6Chao Yan7Jinghua Cui8Hanqing Zhao9Yanling Feng10Junxia Feng11Zheng Fan12Tongtong Fu13Ziying Xu14Yang Yang15Lijuan Huang16Shuo Zhao17Jing Yuan18Department of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Pharmacy, The Third Hospital of Changsha (Changsha Hospital Affiliated to Hunan University), Changsha, Hunan, China; Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs, Changsha, Hunan, China; Institute of Clinical Application of Antibiotics, Changsha, Hunan, ChinaCapital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDepartment of Pharmacy, The Third Hospital of Changsha (Changsha Hospital Affiliated to Hunan University), Changsha, Hunan, China; Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs, Changsha, Hunan, China; Institute of Clinical Application of Antibiotics, Changsha, Hunan, ChinaDepartment of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, China; Corresponding author.Background: The emergence of hypervirulent and antibiotic-resistant Klebsiella pneumoniae isolates poses a significant global public health threat, necessitating stringent prevention and control strategies on an international scale. However, current research efforts are often geographically restricted and lack integration of large-scale data analyses, limiting the understanding of the global prevalence and molecular epidemiology of K. pneumoniae. Furthermore, studies on hypervirulent K. pneumoniae (hvKp) have predominantly emphasized virulence traits, with limited exploration of their associations with molecular subtypes, such as sequence types (STs) and capsule types. Methods: To address these gaps, a total of 55,684K. pneumoniae isolates collected across global regions, were applied in this study to investigate virulence factors, antimicrobial resistance profiles, molecular typing characteristics and the intrinsic connections between these features. Results: Through the application of big data analytics, we generated a comprehensive global distribution map of K. pneumoniae, revealing a higher prevalence of hvKp isolates with high-risk multidrug resistance in Asia. Notably, sequence types ST23, ST65, and ST86 exhibited the highest proportions of hvKp isolates. Regional differences in the virulence potential of specific sequence types were associated with the presence of aerobactin, a key siderophore. Additionally, capsular type KL64 was identified as potentially correlated with hypervirulence. Conclusions: This large-scale genomic surveillance offers critical insights into the global distribution and molecular epidemiology of K. pneumoniae, providing an evidence base for risk mapping and the formulation of tailored control strategies to mitigate the threat posed by this pathogen.http://www.sciencedirect.com/science/article/pii/S1876034125001832Klebsiella pneumoniaeGenomeHypervirulenceHvKp |
| spellingShingle | Lin Gan Pan Mao Ziyan Tian Xin Li Zihui Yu Bing Du Guanhua Xue Chao Yan Jinghua Cui Hanqing Zhao Yanling Feng Junxia Feng Zheng Fan Tongtong Fu Ziying Xu Yang Yang Lijuan Huang Shuo Zhao Jing Yuan Higher prevalence of hypervirulent Klebsiella pneumoniae isolates with high-risk multidrug resistance in Asia Journal of Infection and Public Health Klebsiella pneumoniae Genome Hypervirulence HvKp |
| title | Higher prevalence of hypervirulent Klebsiella pneumoniae isolates with high-risk multidrug resistance in Asia |
| title_full | Higher prevalence of hypervirulent Klebsiella pneumoniae isolates with high-risk multidrug resistance in Asia |
| title_fullStr | Higher prevalence of hypervirulent Klebsiella pneumoniae isolates with high-risk multidrug resistance in Asia |
| title_full_unstemmed | Higher prevalence of hypervirulent Klebsiella pneumoniae isolates with high-risk multidrug resistance in Asia |
| title_short | Higher prevalence of hypervirulent Klebsiella pneumoniae isolates with high-risk multidrug resistance in Asia |
| title_sort | higher prevalence of hypervirulent klebsiella pneumoniae isolates with high risk multidrug resistance in asia |
| topic | Klebsiella pneumoniae Genome Hypervirulence HvKp |
| url | http://www.sciencedirect.com/science/article/pii/S1876034125001832 |
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