Athletic protocol in non-cystic fibrosis-related bronchiectasis: rationale and design of the pilot ATHOS study
Bronchiectasis is a chronic and heterogeneous respiratory condition, which is characterized by irreversible abnormal dilatation of the bronchial tree, chronic cough, copious sputum production, and increased risk of acute exacerbations that contribute to the development of chronic respiratory failure...
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| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1554300/full |
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| author | Francesco Bertuccio Francesco Bertuccio Mitela Tafa Mitela Tafa Denise Carabetta Tiziano Gemelli Giuseppe D’Antona Giuseppe D’Antona Oscar Crisafulli Valentina Conio Valentina Conio Amelia Grosso Amelia Grosso Annalisa De Silvestri Angelo G. Corsico Angelo G. Corsico Giulia M. Stella Giulia M. Stella |
| author_facet | Francesco Bertuccio Francesco Bertuccio Mitela Tafa Mitela Tafa Denise Carabetta Tiziano Gemelli Giuseppe D’Antona Giuseppe D’Antona Oscar Crisafulli Valentina Conio Valentina Conio Amelia Grosso Amelia Grosso Annalisa De Silvestri Angelo G. Corsico Angelo G. Corsico Giulia M. Stella Giulia M. Stella |
| author_sort | Francesco Bertuccio |
| collection | DOAJ |
| description | Bronchiectasis is a chronic and heterogeneous respiratory condition, which is characterized by irreversible abnormal dilatation of the bronchial tree, chronic cough, copious sputum production, and increased risk of acute exacerbations that contribute to the development of chronic respiratory failure, poor exercise tolerance and, consequently, poor quality of life (QoL). A large amount of published data explore regarding the diagnostic approach, the clinical management, and the development of novel therapeutic strategies. Moreover, it is well-known that the exercise-training rehabilitation can be helpful in reducing disease deterioration and relieve symptoms. However, the effect of exercise in patients with non-cystic fibrosis-related bronchiectasis (NCFB) is scarce, and no athletic programs have been fully developed. Thus, the aim of the present study is to investigate the results obtained by administering a specific athletic/physical protocol to these patients. Among all patients affected by NCFB and followed in our Institution, those with the highest scores of performance status will be addressed to the Interdipartimental Centre in Motor and Sport Activities, Sport Medicine Centre, University of Pavia for a work protocol based on mesocycles of 3 times/week for 6 months. A patient-tailored active training regimen will be set up considering major complaints—endurance training for patients with dyspnea, strength training for patients with cough and difficult sputum expectoration, and a balanced aerobic and anaerobic training for patients with asthenia. To the best of our knowledge, the ATHOS study is the first perspective clinical trial, encompassing athletic programs for non-CF bronchiectasis patients, and rationale and in itinere, partial results will be presented, analyzed, and discussed in comparison to standard disease management. |
| format | Article |
| id | doaj-art-49c62b375f7c41f588b6c8d5f128c75d |
| institution | Matheson Library |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-49c62b375f7c41f588b6c8d5f128c75d2025-07-09T05:37:34ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.15543001554300Athletic protocol in non-cystic fibrosis-related bronchiectasis: rationale and design of the pilot ATHOS studyFrancesco Bertuccio0Francesco Bertuccio1Mitela Tafa2Mitela Tafa3Denise Carabetta4Tiziano Gemelli5Giuseppe D’Antona6Giuseppe D’Antona7Oscar Crisafulli8Valentina Conio9Valentina Conio10Amelia Grosso11Amelia Grosso12Annalisa De Silvestri13Angelo G. Corsico14Angelo G. Corsico15Giulia M. Stella16Giulia M. Stella17Department of Internal Medicine and Medical Therapeutics, University of Pavia Medical School, Pavia, ItalyUnit of Respiratory Diseases, Department of Cardiothoracic and Vascular, IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia Medical School, Pavia, ItalyUnit of Respiratory Diseases, Department of Cardiothoracic and Vascular, IRCCS Policlinico San Matteo, Pavia, ItalyInterdepartmental Centre in Motor and Sport Activities, Sport Medicine Centre, University of Pavia, Pavia, ItalyInterdepartmental Centre in Motor and Sport Activities, Sport Medicine Centre, University of Pavia, Pavia, ItalyInterdepartmental Centre in Motor and Sport Activities, Sport Medicine Centre, University of Pavia, Pavia, ItalyDepartment of Public Health, Experimental and Forensic Medicine, University of Pavia Medical School, Pavia, ItalyInterdepartmental Centre in Motor and Sport Activities, Sport Medicine Centre, University of Pavia, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia Medical School, Pavia, ItalyUnit of Respiratory Diseases, Department of Cardiothoracic and Vascular, IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia Medical School, Pavia, ItalyUnit of Respiratory Diseases, Department of Cardiothoracic and Vascular, IRCCS Policlinico San Matteo, Pavia, ItalySSD Biostatistics and Clinical Trial Center, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia Medical School, Pavia, ItalyUnit of Respiratory Diseases, Department of Cardiothoracic and Vascular, IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia Medical School, Pavia, ItalyUnit of Respiratory Diseases, Department of Cardiothoracic and Vascular, IRCCS Policlinico San Matteo, Pavia, ItalyBronchiectasis is a chronic and heterogeneous respiratory condition, which is characterized by irreversible abnormal dilatation of the bronchial tree, chronic cough, copious sputum production, and increased risk of acute exacerbations that contribute to the development of chronic respiratory failure, poor exercise tolerance and, consequently, poor quality of life (QoL). A large amount of published data explore regarding the diagnostic approach, the clinical management, and the development of novel therapeutic strategies. Moreover, it is well-known that the exercise-training rehabilitation can be helpful in reducing disease deterioration and relieve symptoms. However, the effect of exercise in patients with non-cystic fibrosis-related bronchiectasis (NCFB) is scarce, and no athletic programs have been fully developed. Thus, the aim of the present study is to investigate the results obtained by administering a specific athletic/physical protocol to these patients. Among all patients affected by NCFB and followed in our Institution, those with the highest scores of performance status will be addressed to the Interdipartimental Centre in Motor and Sport Activities, Sport Medicine Centre, University of Pavia for a work protocol based on mesocycles of 3 times/week for 6 months. A patient-tailored active training regimen will be set up considering major complaints—endurance training for patients with dyspnea, strength training for patients with cough and difficult sputum expectoration, and a balanced aerobic and anaerobic training for patients with asthenia. To the best of our knowledge, the ATHOS study is the first perspective clinical trial, encompassing athletic programs for non-CF bronchiectasis patients, and rationale and in itinere, partial results will be presented, analyzed, and discussed in comparison to standard disease management.https://www.frontiersin.org/articles/10.3389/fmed.2025.1554300/fullbronchiectasesexacerbationathleticquality of lifeactivity |
| spellingShingle | Francesco Bertuccio Francesco Bertuccio Mitela Tafa Mitela Tafa Denise Carabetta Tiziano Gemelli Giuseppe D’Antona Giuseppe D’Antona Oscar Crisafulli Valentina Conio Valentina Conio Amelia Grosso Amelia Grosso Annalisa De Silvestri Angelo G. Corsico Angelo G. Corsico Giulia M. Stella Giulia M. Stella Athletic protocol in non-cystic fibrosis-related bronchiectasis: rationale and design of the pilot ATHOS study Frontiers in Medicine bronchiectases exacerbation athletic quality of life activity |
| title | Athletic protocol in non-cystic fibrosis-related bronchiectasis: rationale and design of the pilot ATHOS study |
| title_full | Athletic protocol in non-cystic fibrosis-related bronchiectasis: rationale and design of the pilot ATHOS study |
| title_fullStr | Athletic protocol in non-cystic fibrosis-related bronchiectasis: rationale and design of the pilot ATHOS study |
| title_full_unstemmed | Athletic protocol in non-cystic fibrosis-related bronchiectasis: rationale and design of the pilot ATHOS study |
| title_short | Athletic protocol in non-cystic fibrosis-related bronchiectasis: rationale and design of the pilot ATHOS study |
| title_sort | athletic protocol in non cystic fibrosis related bronchiectasis rationale and design of the pilot athos study |
| topic | bronchiectases exacerbation athletic quality of life activity |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1554300/full |
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