DIAGNOSTICS OF BONE METABOLISM DISORDERS IN ONCOLOGICAL DISEASES
Osteoporosis is one of the most significant bone complications of cancer. About 1.5 million cancer patients worldwide have bone metastases. Patients with myeloma, breast cancer, prostate, thyroid, bladder and lung have very high risk of development of bone lesions and related complications. Currentl...
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QUASAR, LLC
2016-01-01
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| Series: | Исследования и практика в медицине |
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| Online Access: | https://www.rpmj.ru/rpmj/article/view/107 |
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| author | O. I. Apolikhin B. Y. Alekseev A. V. Sivkov N. G. Keshishev A. A. Trudov E. Z. Rabinovich A. A. Kachmazov |
| author_facet | O. I. Apolikhin B. Y. Alekseev A. V. Sivkov N. G. Keshishev A. A. Trudov E. Z. Rabinovich A. A. Kachmazov |
| author_sort | O. I. Apolikhin |
| collection | DOAJ |
| description | Osteoporosis is one of the most significant bone complications of cancer. About 1.5 million cancer patients worldwide have bone metastases. Patients with myeloma, breast cancer, prostate, thyroid, bladder and lung have very high risk of development of bone lesions and related complications. Currently, osteodensitometry is the gold standard for the diagnosis of osteoporosis. In recent years we frequently use the innovative imaging techniques for bone metastases, such as CT, MRI, PET/CT. Unfortunately, the diagnostic value of these methods is that it is not always possible to identify abnormalities of bone metabolism in cancer, especially in the early stages. This review shows the world experience of usage of biochemical markers of bone resorption (calcium, hydroxyproline, NTX, CTX, PYD, DPD, TRAP-5b, bone sialoprotein - BSP) and markers of bone synthesis (osteocalcin, CSF, ACF, Karlovy vary IFF), their advantages and disadvantages. The level of these markers is increased in most patients with osteoporosis and bone metastases, it is suggesting a potential role in early diagnosis of bone metastases. |
| format | Article |
| id | doaj-art-4953e1b5bc3c47a2802bd74bdf9da6c8 |
| institution | Matheson Library |
| issn | 2410-1893 |
| language | Russian |
| publishDate | 2016-01-01 |
| publisher | QUASAR, LLC |
| record_format | Article |
| series | Исследования и практика в медицине |
| spelling | doaj-art-4953e1b5bc3c47a2802bd74bdf9da6c82025-08-04T14:04:02ZrusQUASAR, LLCИсследования и практика в медицине2410-18932016-01-0124889710.17709/2409-2231-2015-2-4-88-9779DIAGNOSTICS OF BONE METABOLISM DISORDERS IN ONCOLOGICAL DISEASESO. I. Apolikhin0B. Y. Alekseev1A. V. Sivkov2N. G. Keshishev3A. A. Trudov4E. Z. Rabinovich5A. A. Kachmazov6N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation 3rd Parkovaya ulitsa 51/4, Moscow, 105425, RussiaN. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation 3rd Parkovaya ulitsa 51/4, Moscow, 105425, RussiaN. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation 3rd Parkovaya ulitsa 51/4, Moscow, 105425, RussiaN. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation 3rd Parkovaya ulitsa 51/4, Moscow, 105425, RussiaN. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation 3rd Parkovaya ulitsa 51/4, Moscow, 105425, RussiaN. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation 3rd Parkovaya ulitsa 51/4, Moscow, 105425, RussiaN. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation 3rd Parkovaya ulitsa 51/4, Moscow, 105425, RussiaOsteoporosis is one of the most significant bone complications of cancer. About 1.5 million cancer patients worldwide have bone metastases. Patients with myeloma, breast cancer, prostate, thyroid, bladder and lung have very high risk of development of bone lesions and related complications. Currently, osteodensitometry is the gold standard for the diagnosis of osteoporosis. In recent years we frequently use the innovative imaging techniques for bone metastases, such as CT, MRI, PET/CT. Unfortunately, the diagnostic value of these methods is that it is not always possible to identify abnormalities of bone metabolism in cancer, especially in the early stages. This review shows the world experience of usage of biochemical markers of bone resorption (calcium, hydroxyproline, NTX, CTX, PYD, DPD, TRAP-5b, bone sialoprotein - BSP) and markers of bone synthesis (osteocalcin, CSF, ACF, Karlovy vary IFF), their advantages and disadvantages. The level of these markers is increased in most patients with osteoporosis and bone metastases, it is suggesting a potential role in early diagnosis of bone metastases.https://www.rpmj.ru/rpmj/article/view/107osteoporosisdiagnosis of osteoporosisbiochemical markersbone metastasesbone resorptionsynthesis of bone tissue |
| spellingShingle | O. I. Apolikhin B. Y. Alekseev A. V. Sivkov N. G. Keshishev A. A. Trudov E. Z. Rabinovich A. A. Kachmazov DIAGNOSTICS OF BONE METABOLISM DISORDERS IN ONCOLOGICAL DISEASES Исследования и практика в медицине osteoporosis diagnosis of osteoporosis biochemical markers bone metastases bone resorption synthesis of bone tissue |
| title | DIAGNOSTICS OF BONE METABOLISM DISORDERS IN ONCOLOGICAL DISEASES |
| title_full | DIAGNOSTICS OF BONE METABOLISM DISORDERS IN ONCOLOGICAL DISEASES |
| title_fullStr | DIAGNOSTICS OF BONE METABOLISM DISORDERS IN ONCOLOGICAL DISEASES |
| title_full_unstemmed | DIAGNOSTICS OF BONE METABOLISM DISORDERS IN ONCOLOGICAL DISEASES |
| title_short | DIAGNOSTICS OF BONE METABOLISM DISORDERS IN ONCOLOGICAL DISEASES |
| title_sort | diagnostics of bone metabolism disorders in oncological diseases |
| topic | osteoporosis diagnosis of osteoporosis biochemical markers bone metastases bone resorption synthesis of bone tissue |
| url | https://www.rpmj.ru/rpmj/article/view/107 |
| work_keys_str_mv | AT oiapolikhin diagnosticsofbonemetabolismdisordersinoncologicaldiseases AT byalekseev diagnosticsofbonemetabolismdisordersinoncologicaldiseases AT avsivkov diagnosticsofbonemetabolismdisordersinoncologicaldiseases AT ngkeshishev diagnosticsofbonemetabolismdisordersinoncologicaldiseases AT aatrudov diagnosticsofbonemetabolismdisordersinoncologicaldiseases AT ezrabinovich diagnosticsofbonemetabolismdisordersinoncologicaldiseases AT aakachmazov diagnosticsofbonemetabolismdisordersinoncologicaldiseases |