Monoclonal Antibodies Capable of Inhibiting the Interaction of the Receptor Binding Domain of SARS-CoV-2 Virus with the Angiotensin-Converting Receptor 2 of Human Cells

Monoclonal Antibodies Capable of Inhibiting the Interaction of the Receptor Binding Domain of SARS-CoV-2 Virus with the Angiotensin-Converting Receptor 2 of Human Cells

The aim of the work was to evaluate the ability of monoclonal antibodies to inhibit the interaction of the receptor binding domain (RBD) in S protein of SARS-CoV-2 virus variants, Wuhan-Hu-1 and BQ 1.1, with the angiotensin-converting receptor 2 (ACE2). Materials and methods. In this study, recombin...

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Bibliographic Details
Main Authors: T. A. Ivashchenko, Ya. O. Romanenko, A. S. Kartseva, M. V. Silkina, M. A. Mar’in, A. E. Khlyntseva, N. A. Zeninskaya, I. G. Shemyakin, V. V. Firstova
Format: Article
Language:Russian
Published: Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” 2024-10-01
Series:Проблемы особо опасных инфекций
Subjects:
sars-cov-2
covid-19
monoclonal antibodies
receptor-binding domain
angiotensin-converting enzyme 2
neutralizing activity
Online Access:https://journal.microbe.ru/jour/article/view/2048
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