Pleomorphic Lobular Carcinoma of the Mammary Gland in Women and Female Dogs: A Comparative Clinical-Pathological and Immunophenotypic Analysis
Pleomorphic invasive lobular carcinoma (PILC or PLC) is a malignant breast tumor considered a rare variant of invasive lobular carcinoma in women, characterized morphologically by marked nuclear pleomorphism, with cells resembling plasmacytoid, histiocytoid, or apocrine cells. One of its defining fe...
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2025-06-01
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| author | Evelyn Ane Oliveira Lize Amanda Basaglia Borges Thaynan Cunha Vieira Bárbara Jaime dos Santos Fernanda Rezende Souza Karen Yumi Ribeiro Nakagaki Cristiana Buzelin Nunes Geovanni Dantas Cassali |
| author_facet | Evelyn Ane Oliveira Lize Amanda Basaglia Borges Thaynan Cunha Vieira Bárbara Jaime dos Santos Fernanda Rezende Souza Karen Yumi Ribeiro Nakagaki Cristiana Buzelin Nunes Geovanni Dantas Cassali |
| author_sort | Evelyn Ane Oliveira |
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| description | Pleomorphic invasive lobular carcinoma (PILC or PLC) is a malignant breast tumor considered a rare variant of invasive lobular carcinoma in women, characterized morphologically by marked nuclear pleomorphism, with cells resembling plasmacytoid, histiocytoid, or apocrine cells. One of its defining features is the loss of E-cadherin expression. Considering the biological similarities between species and the limited data available for female dogs, this study aimed to characterize PLC in canines, with an emphasis on its histopathological and immunophenotypic features and its potential applicability as a comparative model. Histopathological analysis of PLC was performed alongside immunohistochemical evaluation using HER2, estrogen receptors (ER), progesterone receptors (PR), E-cadherin, and Ki-67 (cell proliferation indexing) markers. All canine PLCs tested positive for PR, with the majority being negative for ER, and all were negative for HER2 and E-cadherin. In contrast, in women, all cases were positive for ER, most were positive for PR, and all were negative for HER2. The Luminal B molecular subtype was the most frequent in dogs, whereas Luminal A and Luminal B subtypes showed equal prevalence in women. These findings reveal shared and distinct immunophenotypic features between species. The similarities and differences observed emphasize the relevance of the canine model for comparative oncology. Furthermore, the use of spontaneous tumors in immunocompetent dogs in this study strengthens the translational potential of the findings, thereby reinforcing the use of the canine model in breast cancer research and supporting its role within the One Medicine concept. |
| format | Article |
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| language | English |
| publishDate | 2025-06-01 |
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| series | Veterinary Sciences |
| spelling | doaj-art-47a6c65eb2ee48e79e771e717ca1ea862025-06-25T14:30:38ZengMDPI AGVeterinary Sciences2306-73812025-06-0112658710.3390/vetsci12060587Pleomorphic Lobular Carcinoma of the Mammary Gland in Women and Female Dogs: A Comparative Clinical-Pathological and Immunophenotypic AnalysisEvelyn Ane Oliveira0Lize Amanda Basaglia Borges1Thaynan Cunha Vieira2Bárbara Jaime dos Santos3Fernanda Rezende Souza4Karen Yumi Ribeiro Nakagaki5Cristiana Buzelin Nunes6Geovanni Dantas Cassali7Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627, Belo Horizonte 31270-901, BrazilDepartment of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627, Belo Horizonte 31270-901, BrazilDepartment of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627, Belo Horizonte 31270-901, BrazilDepartment of Pathology and Forensic Medicine, Faculty of Medicine, Federal University of Minas Gerais, Av. Prof. Alfredo Balena, 190, Belo Horizonte 30130-100, BrazilDepartment of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627, Belo Horizonte 31270-901, BrazilDepartment of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627, Belo Horizonte 31270-901, BrazilDepartment of Pathology and Forensic Medicine, Faculty of Medicine, Federal University of Minas Gerais, Av. Prof. Alfredo Balena, 190, Belo Horizonte 30130-100, BrazilDepartment of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627, Belo Horizonte 31270-901, BrazilPleomorphic invasive lobular carcinoma (PILC or PLC) is a malignant breast tumor considered a rare variant of invasive lobular carcinoma in women, characterized morphologically by marked nuclear pleomorphism, with cells resembling plasmacytoid, histiocytoid, or apocrine cells. One of its defining features is the loss of E-cadherin expression. Considering the biological similarities between species and the limited data available for female dogs, this study aimed to characterize PLC in canines, with an emphasis on its histopathological and immunophenotypic features and its potential applicability as a comparative model. Histopathological analysis of PLC was performed alongside immunohistochemical evaluation using HER2, estrogen receptors (ER), progesterone receptors (PR), E-cadherin, and Ki-67 (cell proliferation indexing) markers. All canine PLCs tested positive for PR, with the majority being negative for ER, and all were negative for HER2 and E-cadherin. In contrast, in women, all cases were positive for ER, most were positive for PR, and all were negative for HER2. The Luminal B molecular subtype was the most frequent in dogs, whereas Luminal A and Luminal B subtypes showed equal prevalence in women. These findings reveal shared and distinct immunophenotypic features between species. The similarities and differences observed emphasize the relevance of the canine model for comparative oncology. Furthermore, the use of spontaneous tumors in immunocompetent dogs in this study strengthens the translational potential of the findings, thereby reinforcing the use of the canine model in breast cancer research and supporting its role within the One Medicine concept.https://www.mdpi.com/2306-7381/12/6/587caninemammarycarcinomawomanbreastimmunohistochemistry |
| spellingShingle | Evelyn Ane Oliveira Lize Amanda Basaglia Borges Thaynan Cunha Vieira Bárbara Jaime dos Santos Fernanda Rezende Souza Karen Yumi Ribeiro Nakagaki Cristiana Buzelin Nunes Geovanni Dantas Cassali Pleomorphic Lobular Carcinoma of the Mammary Gland in Women and Female Dogs: A Comparative Clinical-Pathological and Immunophenotypic Analysis Veterinary Sciences canine mammary carcinoma woman breast immunohistochemistry |
| title | Pleomorphic Lobular Carcinoma of the Mammary Gland in Women and Female Dogs: A Comparative Clinical-Pathological and Immunophenotypic Analysis |
| title_full | Pleomorphic Lobular Carcinoma of the Mammary Gland in Women and Female Dogs: A Comparative Clinical-Pathological and Immunophenotypic Analysis |
| title_fullStr | Pleomorphic Lobular Carcinoma of the Mammary Gland in Women and Female Dogs: A Comparative Clinical-Pathological and Immunophenotypic Analysis |
| title_full_unstemmed | Pleomorphic Lobular Carcinoma of the Mammary Gland in Women and Female Dogs: A Comparative Clinical-Pathological and Immunophenotypic Analysis |
| title_short | Pleomorphic Lobular Carcinoma of the Mammary Gland in Women and Female Dogs: A Comparative Clinical-Pathological and Immunophenotypic Analysis |
| title_sort | pleomorphic lobular carcinoma of the mammary gland in women and female dogs a comparative clinical pathological and immunophenotypic analysis |
| topic | canine mammary carcinoma woman breast immunohistochemistry |
| url | https://www.mdpi.com/2306-7381/12/6/587 |
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