Lymphatic uptake and pharmacokinetics of lipid conjugated brush PEG polymers is altered by interactions with albumin and lipoproteins

IntroductionIncreased recognition of the role of lymphatics in disease has brought increased focus on the design of lymph-directed delivery systems for imaging agents and therapeutics. Previously, we developed novel brush polyethylene glycol (PEG) polymers functionalized with different lipids and in...

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Bibliographic Details
Main Authors: Mohammad Abdallah, Ian K. Styles, Alexander Mörsdorf, James L. Grace, John F. Quinn, Michael R. Whittaker, Natalie L. Trevaskis
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Physiology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1610791/full
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