ASSESSMENT INNATE IMMUNE RESPONSE IN INFANTS WITH GENERALIZED HERPES INFECTION
Purpose: Identification of new pathogenic mechanisms of generalized herpes infection in newborn infants.Materials and Methods: A clinical and laboratory examination of 48 infants in the early neonatal period. In 22 children (study group), there was a generalized herpes infection. The control group c...
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| Format: | Article |
| Language: | English |
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State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2013-12-01
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| Series: | Медицинский вестник Юга России |
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| Online Access: | https://www.medicalherald.ru/jour/article/view/147 |
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| author | A. Y. Levkovich A. A. Afonin M. A. Levkovich L. V. Kravchenko |
| author_facet | A. Y. Levkovich A. A. Afonin M. A. Levkovich L. V. Kravchenko |
| author_sort | A. Y. Levkovich |
| collection | DOAJ |
| description | Purpose: Identification of new pathogenic mechanisms of generalized herpes infection in newborn infants.Materials and Methods: A clinical and laboratory examination of 48 infants in the early neonatal period. In 22 children (study group), there was a generalized herpes infection. The control group consisted of 26 clinically healthy newborns. The content of pro-and anti-inflammatory cytokines and chemokines (IFN-γ, IFN-α, IL-12, IL-4, MCP- 1) expression of TLR-2 on monocytes of peripheral blood, frequency polymorphism of Arg753Gln TLR-2 gene.Results: Found that the criterion of herpes generalized infection is reduced number of monocytes expressing TLR-2 gene polymorphism Arg753Gln TLR-2, which is associated with a reduced content of IFN-α, IL-12 and IFN-y in the serum.Summary: The development of generalized herpes infection in newborns occurs against violations of the mechanisms of the innate immune response. |
| format | Article |
| id | doaj-art-46ea9f44f9ec4a8e8aabfb177bb8e83c |
| institution | Matheson Library |
| issn | 2219-8075 2618-7876 |
| language | English |
| publishDate | 2013-12-01 |
| publisher | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation |
| record_format | Article |
| series | Медицинский вестник Юга России |
| spelling | doaj-art-46ea9f44f9ec4a8e8aabfb177bb8e83c2025-07-03T16:13:36ZengState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationМедицинский вестник Юга России2219-80752618-78762013-12-0104929410.21886/2219-8075-2013-4-92-94146ASSESSMENT INNATE IMMUNE RESPONSE IN INFANTS WITH GENERALIZED HERPES INFECTIONA. Y. Levkovich0A. A. Afonin1M. A. Levkovich2L. V. Kravchenko3Rostov Scientific and Research Institute of Obstetrics and PediatricsRostov Scientific and Research Institute of Obstetrics and PediatricsRostov Scientific and Research Institute of Obstetrics and PediatricsRostov Scientific and Research Institute of Obstetrics and PediatricsPurpose: Identification of new pathogenic mechanisms of generalized herpes infection in newborn infants.Materials and Methods: A clinical and laboratory examination of 48 infants in the early neonatal period. In 22 children (study group), there was a generalized herpes infection. The control group consisted of 26 clinically healthy newborns. The content of pro-and anti-inflammatory cytokines and chemokines (IFN-γ, IFN-α, IL-12, IL-4, MCP- 1) expression of TLR-2 on monocytes of peripheral blood, frequency polymorphism of Arg753Gln TLR-2 gene.Results: Found that the criterion of herpes generalized infection is reduced number of monocytes expressing TLR-2 gene polymorphism Arg753Gln TLR-2, which is associated with a reduced content of IFN-α, IL-12 and IFN-y in the serum.Summary: The development of generalized herpes infection in newborns occurs against violations of the mechanisms of the innate immune response.https://www.medicalherald.ru/jour/article/view/147prenatal infections.herpes virusimmunity |
| spellingShingle | A. Y. Levkovich A. A. Afonin M. A. Levkovich L. V. Kravchenko ASSESSMENT INNATE IMMUNE RESPONSE IN INFANTS WITH GENERALIZED HERPES INFECTION Медицинский вестник Юга России prenatal infections.herpes virus immunity |
| title | ASSESSMENT INNATE IMMUNE RESPONSE IN INFANTS WITH GENERALIZED HERPES INFECTION |
| title_full | ASSESSMENT INNATE IMMUNE RESPONSE IN INFANTS WITH GENERALIZED HERPES INFECTION |
| title_fullStr | ASSESSMENT INNATE IMMUNE RESPONSE IN INFANTS WITH GENERALIZED HERPES INFECTION |
| title_full_unstemmed | ASSESSMENT INNATE IMMUNE RESPONSE IN INFANTS WITH GENERALIZED HERPES INFECTION |
| title_short | ASSESSMENT INNATE IMMUNE RESPONSE IN INFANTS WITH GENERALIZED HERPES INFECTION |
| title_sort | assessment innate immune response in infants with generalized herpes infection |
| topic | prenatal infections.herpes virus immunity |
| url | https://www.medicalherald.ru/jour/article/view/147 |
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