ASSESSMENT INNATE IMMUNE RESPONSE IN INFANTS WITH GENERALIZED HERPES INFECTION
Purpose: Identification of new pathogenic mechanisms of generalized herpes infection in newborn infants.Materials and Methods: A clinical and laboratory examination of 48 infants in the early neonatal period. In 22 children (study group), there was a generalized herpes infection. The control group c...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2013-12-01
|
| Series: | Медицинский вестник Юга России |
| Subjects: | |
| Online Access: | https://www.medicalherald.ru/jour/article/view/147 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Purpose: Identification of new pathogenic mechanisms of generalized herpes infection in newborn infants.Materials and Methods: A clinical and laboratory examination of 48 infants in the early neonatal period. In 22 children (study group), there was a generalized herpes infection. The control group consisted of 26 clinically healthy newborns. The content of pro-and anti-inflammatory cytokines and chemokines (IFN-γ, IFN-α, IL-12, IL-4, MCP- 1) expression of TLR-2 on monocytes of peripheral blood, frequency polymorphism of Arg753Gln TLR-2 gene.Results: Found that the criterion of herpes generalized infection is reduced number of monocytes expressing TLR-2 gene polymorphism Arg753Gln TLR-2, which is associated with a reduced content of IFN-α, IL-12 and IFN-y in the serum.Summary: The development of generalized herpes infection in newborns occurs against violations of the mechanisms of the innate immune response. |
|---|---|
| ISSN: | 2219-8075 2618-7876 |