Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages

Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages

Abstract Background Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti‐PD‐1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response to anti‐PD‐1 therapy is necessary to design more effective immunotherapies for GBM. This s...

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Bibliographic Details
Main Authors: Rongrong Zhao, Ziwen Pan, Jiawei Qiu, Boyan Li, Yanhua Qi, Zijie Gao, Wei Qiu, Weijie Tang, Xiaofan Guo, Lin Deng, Gang Li, Hao Xue
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Cancer Communications
Subjects:
Anti‐PD‐1 therapy
exosomes
glioblastoma
intergrins
N‐glycosylation
tumor‐associated macrophages
Online Access:https://doi.org/10.1002/cac2.70016
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