CRYOPYRIN ASSOCIATED PERIODIC SYNDROME
Cryopyrin associated periodic syndrome (CAPS) can be represented by various clinical variants of disease course with different severity of clinical manifestations — from mild to severe (FCAS, MWS, NOMID/CINCA). They are caused by mutations of NLRP3 gene, encoding cryopyrin. Mutations of cryopyrin ge...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
"Paediatrician" Publishers LLC
2013-02-01
|
| Series: | Вопросы современной педиатрии |
| Subjects: | |
| Online Access: | https://vsp.spr-journal.ru/jour/article/view/394 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839575615795101696 |
|---|---|
| author | M. Gattorno |
| author_facet | M. Gattorno |
| author_sort | M. Gattorno |
| collection | DOAJ |
| description | Cryopyrin associated periodic syndrome (CAPS) can be represented by various clinical variants of disease course with different severity of clinical manifestations — from mild to severe (FCAS, MWS, NOMID/CINCA). They are caused by mutations of NLRP3 gene, encoding cryopyrin. Mutations of cryopyrin gene in humans lead to excessive and accelerated production of interleukin 1b. The key role of cryopyrin in massive secretion of active form of interleukin 1b suggested the possibility of treatment aimed against this cytokine. |
| format | Article |
| id | doaj-art-45e09a7701b64b809d9859e96d9439b0 |
| institution | Matheson Library |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2013-02-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-45e09a7701b64b809d9859e96d9439b02025-08-04T13:09:28Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352013-02-01121576210.15690/vsp.v12i1.558394CRYOPYRIN ASSOCIATED PERIODIC SYNDROMEM. Gattorno0UO Pediatria II — Reumatologia, Instituto G. Gaslini, GenoaCryopyrin associated periodic syndrome (CAPS) can be represented by various clinical variants of disease course with different severity of clinical manifestations — from mild to severe (FCAS, MWS, NOMID/CINCA). They are caused by mutations of NLRP3 gene, encoding cryopyrin. Mutations of cryopyrin gene in humans lead to excessive and accelerated production of interleukin 1b. The key role of cryopyrin in massive secretion of active form of interleukin 1b suggested the possibility of treatment aimed against this cytokine.https://vsp.spr-journal.ru/jour/article/view/394cryopyrin associated periodic syndromes, nlrp3 gene mutation, interleukin 1β |
| spellingShingle | M. Gattorno CRYOPYRIN ASSOCIATED PERIODIC SYNDROME Вопросы современной педиатрии cryopyrin associated periodic syndromes, nlrp3 gene mutation, interleukin 1β |
| title | CRYOPYRIN ASSOCIATED PERIODIC SYNDROME |
| title_full | CRYOPYRIN ASSOCIATED PERIODIC SYNDROME |
| title_fullStr | CRYOPYRIN ASSOCIATED PERIODIC SYNDROME |
| title_full_unstemmed | CRYOPYRIN ASSOCIATED PERIODIC SYNDROME |
| title_short | CRYOPYRIN ASSOCIATED PERIODIC SYNDROME |
| title_sort | cryopyrin associated periodic syndrome |
| topic | cryopyrin associated periodic syndromes, nlrp3 gene mutation, interleukin 1β |
| url | https://vsp.spr-journal.ru/jour/article/view/394 |
| work_keys_str_mv | AT mgattorno cryopyrinassociatedperiodicsyndrome |