C-reactive protein induced T cell activation is an indirect monocyte-dependent mechanism involving the CD80/CD28 pathway

C-reactive protein induced T cell activation is an indirect monocyte-dependent mechanism involving the CD80/CD28 pathway

IntroductionT cells are major components of the immune system. Their activation requires interaction between the T cell receptor and co-stimulatory molecules, crucial during infection, inflammation, and allogeneic rejection. Monomeric CRP (mCRP) is a known modulator of inflammation and particularly...

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Bibliographic Details
Main Authors: Julia Thomé, Julia Limmer, Teresa Z. Brose, Johannes Zeller, Nina Chevalier, Anna-Lena Schäfer, Laura Schneider, Maike Lind, Thierry Christmann, Marie Dreck, Sheena Kreuzaler, David Braig, Karlheinz Peter, Franziska Pankratz, Steffen U. Eisenhardt
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
C-reactive protein
T cells
monocytes
CD80/CD28 pathway
Belatacept
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1622865/full
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