Contributions of Hepatic Insulin Resistance and Islet β-Cell Dysfunction to the Blood Glucose Spectrum in Newly Diagnosed Type 2 Diabetes Mellitus
Background Our previous studies have investigated the role of hepatic insulin resistance (hepatic IR) and islet β-cell function in the pathogenesis of diabetes. This study aimed to explore the contributions of hepatic IR and islet β-cell dysfunction to the blood glucose spectrum in patients with new...
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| Language: | English |
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Korean Diabetes Association
2025-07-01
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| Series: | Diabetes & Metabolism Journal |
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| Online Access: | http://e-dmj.org/upload/pdf/dmj-2024-0537.pdf |
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| author | Mengge Yang Ying Wei Jia Liu Ying Wang Guang Wang |
| author_facet | Mengge Yang Ying Wei Jia Liu Ying Wang Guang Wang |
| author_sort | Mengge Yang |
| collection | DOAJ |
| description | Background Our previous studies have investigated the role of hepatic insulin resistance (hepatic IR) and islet β-cell function in the pathogenesis of diabetes. This study aimed to explore the contributions of hepatic IR and islet β-cell dysfunction to the blood glucose spectrum in patients with newly diagnosed type 2 diabetes mellitus. Methods Hepatic IR was assessed by the hepatic insulin resistance index (HIRI). Islet β-cell function was assessed by insulin secretion-sensitivity index-2 (ISSI2). The associations between blood glucose spectrum and hepatic IR and ISSI2 were analyzed. Results A total of 707 patients with new-onset diabetes were included. The fasting blood glucose (FBG) and 30 minutes post-load blood glucose elevated with rising HIRI (both P for trend <0.001). The FBG, 30 minutes, 2 hours, and 3 hours post-load blood glucose elevated with decreasing ISSI2 quartiles (all P for trend <0.001). There was a negative correlation between ISSI2 and HIRI after adjusting blood glucose levels (r=–0.199, P<0.001). Conclusion Hepatic IR mainly contributed to FBG and early-phase postprandial plasma glucose, whereas β-cell dysfunction contributed to fasting and postprandial plasma glucose at each phase. |
| format | Article |
| id | doaj-art-44d19e2d35ef4ad2b2dce7d3574d8d66 |
| institution | Matheson Library |
| issn | 2233-6079 2233-6087 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj-art-44d19e2d35ef4ad2b2dce7d3574d8d662025-07-13T23:39:37ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872025-07-0149488389210.4093/dmj.2024.05372919Contributions of Hepatic Insulin Resistance and Islet β-Cell Dysfunction to the Blood Glucose Spectrum in Newly Diagnosed Type 2 Diabetes MellitusMengge Yang0Ying Wei1Jia Liu2Ying Wang3Guang Wang4 Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China Health Management Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaBackground Our previous studies have investigated the role of hepatic insulin resistance (hepatic IR) and islet β-cell function in the pathogenesis of diabetes. This study aimed to explore the contributions of hepatic IR and islet β-cell dysfunction to the blood glucose spectrum in patients with newly diagnosed type 2 diabetes mellitus. Methods Hepatic IR was assessed by the hepatic insulin resistance index (HIRI). Islet β-cell function was assessed by insulin secretion-sensitivity index-2 (ISSI2). The associations between blood glucose spectrum and hepatic IR and ISSI2 were analyzed. Results A total of 707 patients with new-onset diabetes were included. The fasting blood glucose (FBG) and 30 minutes post-load blood glucose elevated with rising HIRI (both P for trend <0.001). The FBG, 30 minutes, 2 hours, and 3 hours post-load blood glucose elevated with decreasing ISSI2 quartiles (all P for trend <0.001). There was a negative correlation between ISSI2 and HIRI after adjusting blood glucose levels (r=–0.199, P<0.001). Conclusion Hepatic IR mainly contributed to FBG and early-phase postprandial plasma glucose, whereas β-cell dysfunction contributed to fasting and postprandial plasma glucose at each phase.http://e-dmj.org/upload/pdf/dmj-2024-0537.pdfdiabetes mellitus, type 2blood glucoseinsulin resistanceinsulin secretion |
| spellingShingle | Mengge Yang Ying Wei Jia Liu Ying Wang Guang Wang Contributions of Hepatic Insulin Resistance and Islet β-Cell Dysfunction to the Blood Glucose Spectrum in Newly Diagnosed Type 2 Diabetes Mellitus Diabetes & Metabolism Journal diabetes mellitus, type 2 blood glucose insulin resistance insulin secretion |
| title | Contributions of Hepatic Insulin Resistance and Islet β-Cell Dysfunction to the Blood Glucose Spectrum in Newly Diagnosed Type 2 Diabetes Mellitus |
| title_full | Contributions of Hepatic Insulin Resistance and Islet β-Cell Dysfunction to the Blood Glucose Spectrum in Newly Diagnosed Type 2 Diabetes Mellitus |
| title_fullStr | Contributions of Hepatic Insulin Resistance and Islet β-Cell Dysfunction to the Blood Glucose Spectrum in Newly Diagnosed Type 2 Diabetes Mellitus |
| title_full_unstemmed | Contributions of Hepatic Insulin Resistance and Islet β-Cell Dysfunction to the Blood Glucose Spectrum in Newly Diagnosed Type 2 Diabetes Mellitus |
| title_short | Contributions of Hepatic Insulin Resistance and Islet β-Cell Dysfunction to the Blood Glucose Spectrum in Newly Diagnosed Type 2 Diabetes Mellitus |
| title_sort | contributions of hepatic insulin resistance and islet β cell dysfunction to the blood glucose spectrum in newly diagnosed type 2 diabetes mellitus |
| topic | diabetes mellitus, type 2 blood glucose insulin resistance insulin secretion |
| url | http://e-dmj.org/upload/pdf/dmj-2024-0537.pdf |
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