Initial Meropenem Plasma Concentration and Its Correlation with Sepsis Mortality: A Real-World Retrospective Study
Zi Wei Deng,1,2,* Wei Fu,3,* Feng Chen,1 Hong Qiang Wang,1 Yin Hua Deng,4 Yan Yan5 1Department of Clinical Pharmacy, Hunan University of Medicine General Hospital, Huaihua, Hunan, People’s Republic of China; 2Evidence-Based Medicine and Clinical Center, Hunan University of Me...
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Dove Medical Press
2025-08-01
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| author | Deng ZW Fu W Chen F Wang HQ Deng YH Yan Y |
| author_facet | Deng ZW Fu W Chen F Wang HQ Deng YH Yan Y |
| author_sort | Deng ZW |
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| description | Zi Wei Deng,1,2,* Wei Fu,3,* Feng Chen,1 Hong Qiang Wang,1 Yin Hua Deng,4 Yan Yan5 1Department of Clinical Pharmacy, Hunan University of Medicine General Hospital, Huaihua, Hunan, People’s Republic of China; 2Evidence-Based Medicine and Clinical Center, Hunan University of Medicine General Hospital, Huaihua, Hunan, People’s Republic of China; 3Center for Infectious Diseases, Hunan University of Medicine General Hospital, Huaihua, Hunan, People’s Republic of China; 4Department of Medical Administration, Hunan People’s Hospital, Changsha, Hunan, People’s Republic of China; 5Hunan University of Medicine, Huaihua, Hunan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yin Hua Deng, Email dengyinhua244@hunnu.edu.cn Yan Yan, Email 1211952737@qq.comPurpose: Meropenem is a first-line antibiotic for sepsis in settings with high prevalence of multidrug-resistant organisms due to its broad-spectrum activity. However, the relationship between meropenem plasma concentration and prognosis of sepsis is unclear. This study aims to investigate whether optimizing meropenem plasma levels improves 28-day outcomes in sepsis patients, while also exploring the potential impact of continuous versus intermittent infusion methods.Patients and Methods: This real-world retrospective study included 202 sepsis patients treated with meropenem at Hunan University of Medicine General Hospital from January 2022 to December 2023. Patients received either prolonged intravenous infusion or intermittent intravenous infusion of meropenem, as determined by the attending physician. Prolonged infusion involved a 3-hour duration with an infusion pump, while intermittent infusion lasted 30 minutes to 1 hour. Patients were grouped by the quartiles of meropenem plasma concentration (Q1, Q2, Q3, and Q4) to facilitate analysis of dose-response relationships and control for variability in plasma concentration distributions. Mortality rates at 7, 14, and 28 days, as well as the detection rates of resistant bacteria and ICU length of stay, were compared among groups.Results: Prolonged intravenous infusion yielded higher meropenem plasma concentrations compared to intermittent infusion (P=0.024), aligning with expected therapeutic targets for optimal antimicrobial efficacy. However, no significant differences were observed in mortality rates at 7, 14, and 28 days between infusion methods or across plasma concentration quartiles. Multivariable logistic regression confirmed these findings after adjusting for confounding factors. Additionally, no significant differences were found in resistant bacteria detection rates or ICU length of stay across quartiles.Conclusion: While prolonged infusion increases plasma meropenem concentration, it does not impact 28-day mortality risk, ICU stay, or resistant bacteria detection in sepsis patients. These findings suggest that prolonged infusion may not offer significant clinical advantages over intermittent infusion and highlight the importance of balancing antibiotic use with stewardship principles (Graphical abstract). Keywords: meropenem, concentration, sepsis, mortality |
| format | Article |
| id | doaj-art-4402fed4b0bc4d69ac34d0de2bc1b38a |
| institution | Matheson Library |
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| publishDate | 2025-08-01 |
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| series | Infection and Drug Resistance |
| spelling | doaj-art-4402fed4b0bc4d69ac34d0de2bc1b38a2025-08-03T18:34:49ZengDove Medical PressInfection and Drug Resistance1178-69732025-08-01Volume 18Issue 138473857105382Initial Meropenem Plasma Concentration and Its Correlation with Sepsis Mortality: A Real-World Retrospective StudyDeng ZW0Fu WChen FWang HQDeng YH1Yan Y2Pharmacy departmentPharmacy Departmentschool of laboratory medicalZi Wei Deng,1,2,* Wei Fu,3,* Feng Chen,1 Hong Qiang Wang,1 Yin Hua Deng,4 Yan Yan5 1Department of Clinical Pharmacy, Hunan University of Medicine General Hospital, Huaihua, Hunan, People’s Republic of China; 2Evidence-Based Medicine and Clinical Center, Hunan University of Medicine General Hospital, Huaihua, Hunan, People’s Republic of China; 3Center for Infectious Diseases, Hunan University of Medicine General Hospital, Huaihua, Hunan, People’s Republic of China; 4Department of Medical Administration, Hunan People’s Hospital, Changsha, Hunan, People’s Republic of China; 5Hunan University of Medicine, Huaihua, Hunan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yin Hua Deng, Email dengyinhua244@hunnu.edu.cn Yan Yan, Email 1211952737@qq.comPurpose: Meropenem is a first-line antibiotic for sepsis in settings with high prevalence of multidrug-resistant organisms due to its broad-spectrum activity. However, the relationship between meropenem plasma concentration and prognosis of sepsis is unclear. This study aims to investigate whether optimizing meropenem plasma levels improves 28-day outcomes in sepsis patients, while also exploring the potential impact of continuous versus intermittent infusion methods.Patients and Methods: This real-world retrospective study included 202 sepsis patients treated with meropenem at Hunan University of Medicine General Hospital from January 2022 to December 2023. Patients received either prolonged intravenous infusion or intermittent intravenous infusion of meropenem, as determined by the attending physician. Prolonged infusion involved a 3-hour duration with an infusion pump, while intermittent infusion lasted 30 minutes to 1 hour. Patients were grouped by the quartiles of meropenem plasma concentration (Q1, Q2, Q3, and Q4) to facilitate analysis of dose-response relationships and control for variability in plasma concentration distributions. Mortality rates at 7, 14, and 28 days, as well as the detection rates of resistant bacteria and ICU length of stay, were compared among groups.Results: Prolonged intravenous infusion yielded higher meropenem plasma concentrations compared to intermittent infusion (P=0.024), aligning with expected therapeutic targets for optimal antimicrobial efficacy. However, no significant differences were observed in mortality rates at 7, 14, and 28 days between infusion methods or across plasma concentration quartiles. Multivariable logistic regression confirmed these findings after adjusting for confounding factors. Additionally, no significant differences were found in resistant bacteria detection rates or ICU length of stay across quartiles.Conclusion: While prolonged infusion increases plasma meropenem concentration, it does not impact 28-day mortality risk, ICU stay, or resistant bacteria detection in sepsis patients. These findings suggest that prolonged infusion may not offer significant clinical advantages over intermittent infusion and highlight the importance of balancing antibiotic use with stewardship principles (Graphical abstract). Keywords: meropenem, concentration, sepsis, mortalityhttps://www.dovepress.com/initial-meropenem-plasma-concentration-and-its-correlation-with-sepsis-peer-reviewed-fulltext-article-IDRMeropenemConcentrationSepsisMortality |
| spellingShingle | Deng ZW Fu W Chen F Wang HQ Deng YH Yan Y Initial Meropenem Plasma Concentration and Its Correlation with Sepsis Mortality: A Real-World Retrospective Study Infection and Drug Resistance Meropenem Concentration Sepsis Mortality |
| title | Initial Meropenem Plasma Concentration and Its Correlation with Sepsis Mortality: A Real-World Retrospective Study |
| title_full | Initial Meropenem Plasma Concentration and Its Correlation with Sepsis Mortality: A Real-World Retrospective Study |
| title_fullStr | Initial Meropenem Plasma Concentration and Its Correlation with Sepsis Mortality: A Real-World Retrospective Study |
| title_full_unstemmed | Initial Meropenem Plasma Concentration and Its Correlation with Sepsis Mortality: A Real-World Retrospective Study |
| title_short | Initial Meropenem Plasma Concentration and Its Correlation with Sepsis Mortality: A Real-World Retrospective Study |
| title_sort | initial meropenem plasma concentration and its correlation with sepsis mortality a real world retrospective study |
| topic | Meropenem Concentration Sepsis Mortality |
| url | https://www.dovepress.com/initial-meropenem-plasma-concentration-and-its-correlation-with-sepsis-peer-reviewed-fulltext-article-IDR |
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