Gut-Microbiome Signatures Predicting Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review

Gut-Microbiome Signatures Predicting Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review

Background and Objectives: Rectal cancer management increasingly relies on watch-and-wait strategies after neoadjuvant chemoradiotherapy (nCRT). Accurate, non-invasive prediction of pathological complete response (pCR) remains elusive. Emerging evidence suggests that gut-microbiome composition modul...

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Bibliographic Details
Main Authors: Ielmina Domilescu, Bogdan Miutescu, Florin George Horhat, Alina Popescu, Camelia Nica, Ana Maria Ghiuchici, Eyad Gadour, Ioan Sîrbu, Delia Hutanu
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Metabolites
Subjects:
rectal cancer
gut microbiome
chemoradiotherapy
pathologic complete response
predictive biomarker
metagenomics
Online Access:https://www.mdpi.com/2218-1989/15/6/412
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