Сardioprotective agents with biaromatic structure. Part 4. Potassium hERG channels blockers and modulators
The hERG subtype potassium channel (Kv11.1) is one of the most important and one of the most studied biological targets for the creation of cardioprotective agents. A large number of both blockers and activators/modulators of the hERG channel have been described with biaromatic structure. Substances...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2023-01-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/338 |
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| author | G. V. Mokrov |
| author_facet | G. V. Mokrov |
| author_sort | G. V. Mokrov |
| collection | DOAJ |
| description | The hERG subtype potassium channel (Kv11.1) is one of the most important and one of the most studied biological targets for the creation of cardioprotective agents. A large number of both blockers and activators/modulators of the hERG channel have been described with biaromatic structure. Substances with an hERG-mechanism are used primarily for the effective regulation of the action potential duration in the heart tissues and for the control of the QT interval on the electrocardiogram. Among the hERG blockers, the most well-known drug is dofetilide, which is used to maintain sinus rhythm in atrial fibrillation. The review presents all currently known ligands of the hERG channel with a biaromatic structure and the data on their biological properties. |
| format | Article |
| id | doaj-art-43a1aac1c6584e51b74bcc85df18821e |
| institution | Matheson Library |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2023-01-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-43a1aac1c6584e51b74bcc85df18821e2025-08-03T13:00:47ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302023-01-010431910.37489/2587-7836-2022-4-3-19314Сardioprotective agents with biaromatic structure. Part 4. Potassium hERG channels blockers and modulatorsG. V. Mokrov0FSBI «Zakusov Institute of Pharmacology»The hERG subtype potassium channel (Kv11.1) is one of the most important and one of the most studied biological targets for the creation of cardioprotective agents. A large number of both blockers and activators/modulators of the hERG channel have been described with biaromatic structure. Substances with an hERG-mechanism are used primarily for the effective regulation of the action potential duration in the heart tissues and for the control of the QT interval on the electrocardiogram. Among the hERG blockers, the most well-known drug is dofetilide, which is used to maintain sinus rhythm in atrial fibrillation. The review presents all currently known ligands of the hERG channel with a biaromatic structure and the data on their biological properties.https://www.pharmacokinetica.ru/jour/article/view/338antiarrhythmicscardioprotectorsherg channel blockersherg channel activators/modulatorsbiaromatic compounds |
| spellingShingle | G. V. Mokrov Сardioprotective agents with biaromatic structure. Part 4. Potassium hERG channels blockers and modulators Фармакокинетика и Фармакодинамика antiarrhythmics cardioprotectors herg channel blockers herg channel activators/modulators biaromatic compounds |
| title | Сardioprotective agents with biaromatic structure. Part 4. Potassium hERG channels blockers and modulators |
| title_full | Сardioprotective agents with biaromatic structure. Part 4. Potassium hERG channels blockers and modulators |
| title_fullStr | Сardioprotective agents with biaromatic structure. Part 4. Potassium hERG channels blockers and modulators |
| title_full_unstemmed | Сardioprotective agents with biaromatic structure. Part 4. Potassium hERG channels blockers and modulators |
| title_short | Сardioprotective agents with biaromatic structure. Part 4. Potassium hERG channels blockers and modulators |
| title_sort | сardioprotective agents with biaromatic structure part 4 potassium herg channels blockers and modulators |
| topic | antiarrhythmics cardioprotectors herg channel blockers herg channel activators/modulators biaromatic compounds |
| url | https://www.pharmacokinetica.ru/jour/article/view/338 |
| work_keys_str_mv | AT gvmokrov sardioprotectiveagentswithbiaromaticstructurepart4potassiumhergchannelsblockersandmodulators |