Optimal Primary Prophylaxis for Febrile Neutropenia During Neoadjuvant Cisplatin and 5‐Fluorouracil Plus Docetaxel for Esophageal Cancer: A Retrospective Cohort Study

Optimal Primary Prophylaxis for Febrile Neutropenia During Neoadjuvant Cisplatin and 5‐Fluorouracil Plus Docetaxel for Esophageal Cancer: A Retrospective Cohort Study

ABSTRACT Background Neoadjuvant chemotherapy (NAC) with docetaxel, cisplatin, and 5‐fluorouracil (5‐FU) (DCF) is the standard treatment for locally advanced esophageal cancer (LAEC). DCF is associated with a high risk of febrile neutropenia (FN), but the optimal primary prophylaxis remains unclear....

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Main Authors: Ryosuke Kumanishi, Hiroya Taniguchi, Taiko Nakazawa, Takatsugu Ogata, Yuki Matsubara, Hiroyuki Kodama, Akinobu Nakata, Kazunori Honda, Toshiki Masuishi, Yukiya Narita, Shigenori Kadowaki, Masashi Ando, Masahiro Tajika, Tetsuya Abe, Kei Muro
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Cancer Medicine
Subjects:
5‐fluorouracil
cisplatin
docetaxel
esophageal cancer
febrile neutropenia
neoadjuvant chemotherapy
Online Access:https://doi.org/10.1002/cam4.70889
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