Case report of a squamous cell carcinoma arising in a vulvar cutaneous horn

Background: Cutaneous horns are rare lesions that consist of a proliferation of keratotic material, often representing animal horns. Rarely, they may be associated with underlying squamous cell carcinomas. Here, we present a case report of a cutaneous horn arising in a squamous cell carcinoma of the...

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Main Authors: Michael Bell, Erin Crane, Robert Tucker Burks
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Gynecologic Oncology Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2352578925001092
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author Michael Bell
Erin Crane
Robert Tucker Burks
author_facet Michael Bell
Erin Crane
Robert Tucker Burks
author_sort Michael Bell
collection DOAJ
description Background: Cutaneous horns are rare lesions that consist of a proliferation of keratotic material, often representing animal horns. Rarely, they may be associated with underlying squamous cell carcinomas. Here, we present a case report of a cutaneous horn arising in a squamous cell carcinoma of the vulva. Objective: In this report, we highlight the case of an 84 year-old patient who presented with a vulvar cutaneous horn. After resection, pathology demonstrated an invasive squamous cell carcinoma of the vulva. We provide a review of available literature and describe a rare manifestation of a squamous cell carcinoma of the vulva. Given her frailty, no further treatment was pursued, and she remains in observation without evidence of recurrence. Conclusions: Our case highlights a rare presentation of a vulvar cutaneous horn arising within invasive squamous cell carcinoma of the vulva. While most cutaneous horns are benign, a subset may harbor malignancy, and therefore excision is warranted. Additional treatment is dependent upon histopathology, disease site, and patient factors.
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spelling doaj-art-41e138766fa44811907871e7e29dbcfe2025-06-28T05:30:25ZengElsevierGynecologic Oncology Reports2352-57892025-08-0160101784Case report of a squamous cell carcinoma arising in a vulvar cutaneous hornMichael Bell0Erin Crane1Robert Tucker Burks2Department of Obstetrics and Gynecology, Atrium Health Carolinas Medical Center, Charlotte, North Carolina, United States; Corresponding author.Wake Forest University School of Medicine, Department of Obstetrics and Gynecology, Department of Gynecologic Oncology, Atrium Health Carolinas Medical Center, Levine Cancer Institute, Charlotte, North Carolina, United StatesCarolinas Pathology Group, Charlotte, North Carolina, United StatesBackground: Cutaneous horns are rare lesions that consist of a proliferation of keratotic material, often representing animal horns. Rarely, they may be associated with underlying squamous cell carcinomas. Here, we present a case report of a cutaneous horn arising in a squamous cell carcinoma of the vulva. Objective: In this report, we highlight the case of an 84 year-old patient who presented with a vulvar cutaneous horn. After resection, pathology demonstrated an invasive squamous cell carcinoma of the vulva. We provide a review of available literature and describe a rare manifestation of a squamous cell carcinoma of the vulva. Given her frailty, no further treatment was pursued, and she remains in observation without evidence of recurrence. Conclusions: Our case highlights a rare presentation of a vulvar cutaneous horn arising within invasive squamous cell carcinoma of the vulva. While most cutaneous horns are benign, a subset may harbor malignancy, and therefore excision is warranted. Additional treatment is dependent upon histopathology, disease site, and patient factors.http://www.sciencedirect.com/science/article/pii/S2352578925001092Cutaneous HornVulvar cancerSquamous Cell Carcinoma
spellingShingle Michael Bell
Erin Crane
Robert Tucker Burks
Case report of a squamous cell carcinoma arising in a vulvar cutaneous horn
Gynecologic Oncology Reports
Cutaneous Horn
Vulvar cancer
Squamous Cell Carcinoma
title Case report of a squamous cell carcinoma arising in a vulvar cutaneous horn
title_full Case report of a squamous cell carcinoma arising in a vulvar cutaneous horn
title_fullStr Case report of a squamous cell carcinoma arising in a vulvar cutaneous horn
title_full_unstemmed Case report of a squamous cell carcinoma arising in a vulvar cutaneous horn
title_short Case report of a squamous cell carcinoma arising in a vulvar cutaneous horn
title_sort case report of a squamous cell carcinoma arising in a vulvar cutaneous horn
topic Cutaneous Horn
Vulvar cancer
Squamous Cell Carcinoma
url http://www.sciencedirect.com/science/article/pii/S2352578925001092
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