Adiponectin , ?-Cell Dysfunction in Iraqi Women with Gestational Diabetes
Gestational diabetes mellitus (GDM) is a complication of gestation that is characterized by impaired glucose tolerance with first recognition during gestation. It develops when ?- cell of pancreas fail to compensate the diminished insulin sensitivity during gestation. This study aims to investigate...
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University of Baghdad, College of Science for Women
2016-06-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2781 |
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| description | Gestational diabetes mellitus (GDM) is a complication of gestation that is characterized by impaired glucose tolerance with first recognition during gestation. It develops when ?- cell of pancreas fail to compensate the diminished insulin sensitivity during gestation. This study aims to investigate the relationship between mother adiponectin level and ?- cell dysfunction with development gestational diabetes mellitus (GDM) and other parameters in the last trimester of pregnancy. This study includes (80) subjects ( pregnant women) in the third trimester of pregnancy, (40) healthy pregnant individuals as control group aged between (17 - 42) years and (40) gestational diabetes mellitus patients with aged between (20 - 42) years. The following biochemical investigation is studied: oral glucose tolerance test (OGTT), adiponectin , insulin, C-reactive protein (CRP),body mass index (BMI), and homeostasis model assessment- insulin resistance (HOMA – IR). The adiponectin levels are significantly lesser in females who develop GDM than the control group (P?0.01), while the insulin and OGTT concentrations were significantly higher in females with GDM than control group (P?0.01).The concentrations of CRP are non significantly different between the females who develop GDM and the control group.Conclusions: Lower adiponectin concentrations are associated with an increased risk of the development of gestational diabetes mellitus and females, who develop gestational diabetes mellitus, have higher levels of insulin resistance from normal females, Obesity is a shape of persistent low grade inflammation which causes elevated concentrations of C- reactive protein. |
| format | Article |
| id | doaj-art-41cde49696874a30b9469d517b986b33 |
| institution | Matheson Library |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-41cde49696874a30b9469d517b986b332025-08-02T06:18:39ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862016-06-0113210.21123/bsj.13.2.366-374Adiponectin , ?-Cell Dysfunction in Iraqi Women with Gestational DiabetesBaghdad Science JournalGestational diabetes mellitus (GDM) is a complication of gestation that is characterized by impaired glucose tolerance with first recognition during gestation. It develops when ?- cell of pancreas fail to compensate the diminished insulin sensitivity during gestation. This study aims to investigate the relationship between mother adiponectin level and ?- cell dysfunction with development gestational diabetes mellitus (GDM) and other parameters in the last trimester of pregnancy. This study includes (80) subjects ( pregnant women) in the third trimester of pregnancy, (40) healthy pregnant individuals as control group aged between (17 - 42) years and (40) gestational diabetes mellitus patients with aged between (20 - 42) years. The following biochemical investigation is studied: oral glucose tolerance test (OGTT), adiponectin , insulin, C-reactive protein (CRP),body mass index (BMI), and homeostasis model assessment- insulin resistance (HOMA – IR). The adiponectin levels are significantly lesser in females who develop GDM than the control group (P?0.01), while the insulin and OGTT concentrations were significantly higher in females with GDM than control group (P?0.01).The concentrations of CRP are non significantly different between the females who develop GDM and the control group.Conclusions: Lower adiponectin concentrations are associated with an increased risk of the development of gestational diabetes mellitus and females, who develop gestational diabetes mellitus, have higher levels of insulin resistance from normal females, Obesity is a shape of persistent low grade inflammation which causes elevated concentrations of C- reactive protein.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2781"Gestational Diabetes Mellitus (GDM), Adiponectin, Beta Cell Dysfunction, Insulin, Oral Glucose Tolerance Test (OGTT), C-Reactive Protein (CRP). " |
| spellingShingle | Baghdad Science Journal Adiponectin , ?-Cell Dysfunction in Iraqi Women with Gestational Diabetes مجلة بغداد للعلوم "Gestational Diabetes Mellitus (GDM), Adiponectin, Beta Cell Dysfunction, Insulin, Oral Glucose Tolerance Test (OGTT), C-Reactive Protein (CRP). " |
| title | Adiponectin , ?-Cell Dysfunction in Iraqi Women with Gestational Diabetes |
| title_full | Adiponectin , ?-Cell Dysfunction in Iraqi Women with Gestational Diabetes |
| title_fullStr | Adiponectin , ?-Cell Dysfunction in Iraqi Women with Gestational Diabetes |
| title_full_unstemmed | Adiponectin , ?-Cell Dysfunction in Iraqi Women with Gestational Diabetes |
| title_short | Adiponectin , ?-Cell Dysfunction in Iraqi Women with Gestational Diabetes |
| title_sort | adiponectin cell dysfunction in iraqi women with gestational diabetes |
| topic | "Gestational Diabetes Mellitus (GDM), Adiponectin, Beta Cell Dysfunction, Insulin, Oral Glucose Tolerance Test (OGTT), C-Reactive Protein (CRP). " |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2781 |
| work_keys_str_mv | AT baghdadsciencejournal adiponectincelldysfunctioniniraqiwomenwithgestationaldiabetes |