Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for Analysis of Riluzole in Human Plasma and Its Application on a Bioequivalence Study

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Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for Analysis of Riluzole in Human Plasma and Its Application on a Bioequivalence Study

Introduction. As the first approved drug for amyotrophic lateral sclerosis (ALS) treatment, riluzole is known as a glutamatergic neurotransmission inhibitor administrated in 50 mg tablets twice daily. For this reason, a generic product of riluzole has been developed at a lower price by Hogar-Daroo,...

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Bibliographic Details
Main Authors:	S. Mohammadzadeh, F. Salmannejad, M. Mohammadzadeh, T. Ghari, S. Sadrai, J. Zaringhalam
Format:	Article
Language:	Russian
Published:	LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2023-02-01
Series:	Разработка и регистрация лекарственных средств
Subjects:	riluzole amyotrophic lateral sclerosis bioequivalence lc-ms/ms validation pharmacokinetics
Online Access:	https://www.pharmjournal.ru/jour/article/view/1449
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