Diagnosis and Correction of Impaired Lipid Peroxidation in Terminal States: Experimental Study
Ischemic and early postresuscitative lipid peroxidation (LPO) changes in the cortex and subcortical structures of the brain, the left and Spiegelian lobes of the liver, the cortex and medulla of the kidney, and plasma were studied in experiments on cats, by using a model of 5-minute clinical death f...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2006-12-01
|
| Series: | Общая реаниматология |
| Subjects: | |
| Online Access: | https://www.reanimatology.com/rmt/article/view/1377 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839578531604987904 |
|---|---|
| author | A. S. Razumov A. Ya. Yevtushenko |
| author_facet | A. S. Razumov A. Ya. Yevtushenko |
| author_sort | A. S. Razumov |
| collection | DOAJ |
| description | Ischemic and early postresuscitative lipid peroxidation (LPO) changes in the cortex and subcortical structures of the brain, the left and Spiegelian lobes of the liver, the cortex and medulla of the kidney, and plasma were studied in experiments on cats, by using a model of 5-minute clinical death from long-term blood loss. At death and in the early postresuscitative period, the LPO changes were ascertained to have qualitative, quantitative, and temporary differences not only in various organs, but also in various structures of the same organ. Excessive reperfusion was shown to play a leading role in postresuscitative LPO activation in the brain. At the same time, the high rate of LPO was not always followed by adequate tissue and plasma accumulation of LPO products and it was revealed only in rather long incubation of homogenates. Not only hyperreperfusion activation of lipid peroxidation, but also its excessive inhibition caused by antioxidantive agents was established to adversely affect resuscitation after a prior terminal condition. |
| format | Article |
| id | doaj-art-41ac6a935a324a2c8b51e58361fae1f9 |
| institution | Matheson Library |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2006-12-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-41ac6a935a324a2c8b51e58361fae1f92025-08-04T10:40:37ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102006-12-012614615210.15360/1813-9779-2006-6-146-1521377Diagnosis and Correction of Impaired Lipid Peroxidation in Terminal States: Experimental StudyA. S. Razumov0A. Ya. Yevtushenko1Kemerovo State Medical Academy Department of Biochemistry, Department of Pathological PhysiologyKemerovo State Medical Academy Department of Biochemistry, Department of Pathological PhysiologyIschemic and early postresuscitative lipid peroxidation (LPO) changes in the cortex and subcortical structures of the brain, the left and Spiegelian lobes of the liver, the cortex and medulla of the kidney, and plasma were studied in experiments on cats, by using a model of 5-minute clinical death from long-term blood loss. At death and in the early postresuscitative period, the LPO changes were ascertained to have qualitative, quantitative, and temporary differences not only in various organs, but also in various structures of the same organ. Excessive reperfusion was shown to play a leading role in postresuscitative LPO activation in the brain. At the same time, the high rate of LPO was not always followed by adequate tissue and plasma accumulation of LPO products and it was revealed only in rather long incubation of homogenates. Not only hyperreperfusion activation of lipid peroxidation, but also its excessive inhibition caused by antioxidantive agents was established to adversely affect resuscitation after a prior terminal condition.https://www.reanimatology.com/rmt/article/view/1377lipid peroxidationantioxidantsischemiareperfusiondiagnosiscorrectionresuscitation |
| spellingShingle | A. S. Razumov A. Ya. Yevtushenko Diagnosis and Correction of Impaired Lipid Peroxidation in Terminal States: Experimental Study Общая реаниматология lipid peroxidation antioxidants ischemia reperfusion diagnosis correction resuscitation |
| title | Diagnosis and Correction of Impaired Lipid Peroxidation in Terminal States: Experimental Study |
| title_full | Diagnosis and Correction of Impaired Lipid Peroxidation in Terminal States: Experimental Study |
| title_fullStr | Diagnosis and Correction of Impaired Lipid Peroxidation in Terminal States: Experimental Study |
| title_full_unstemmed | Diagnosis and Correction of Impaired Lipid Peroxidation in Terminal States: Experimental Study |
| title_short | Diagnosis and Correction of Impaired Lipid Peroxidation in Terminal States: Experimental Study |
| title_sort | diagnosis and correction of impaired lipid peroxidation in terminal states experimental study |
| topic | lipid peroxidation antioxidants ischemia reperfusion diagnosis correction resuscitation |
| url | https://www.reanimatology.com/rmt/article/view/1377 |
| work_keys_str_mv | AT asrazumov diagnosisandcorrectionofimpairedlipidperoxidationinterminalstatesexperimentalstudy AT ayayevtushenko diagnosisandcorrectionofimpairedlipidperoxidationinterminalstatesexperimentalstudy |