Rare cases of laboratory tests discrepancies in diagnostics of pediatric Burkitt lymphoma/leukemia
Introduction. The main features of bone marrow blasts cells in Burkitt lymphoma/leukemia (BL) are L3 morphology, mature immunophenotype of blasts with surface IgM expression, and presence of typical MYC gene rearrangements.The aim of the study was to show discrepancy examples in laboratory signs of...
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2018-10-01
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| author | I. A. Demina O. I. Illarionova1 T. Yu. Verzhbitskaya G. A. Tsaur E. B. Rusanova M. V. Gorchakova E. E. Zueva M. B. Belogurova G. I. Uleiskaya L. A. Shchekina A. N. Kazakova E. A. Zerkalenkova Yu. V. Olshanskaya Yu. G. Abugova l. G. Fechina N. V. Miakova E. V. Samochatova A. A. Maschan A. M. Popov |
| author_facet | I. A. Demina O. I. Illarionova1 T. Yu. Verzhbitskaya G. A. Tsaur E. B. Rusanova M. V. Gorchakova E. E. Zueva M. B. Belogurova G. I. Uleiskaya L. A. Shchekina A. N. Kazakova E. A. Zerkalenkova Yu. V. Olshanskaya Yu. G. Abugova l. G. Fechina N. V. Miakova E. V. Samochatova A. A. Maschan A. M. Popov |
| author_sort | I. A. Demina |
| collection | DOAJ |
| description | Introduction. The main features of bone marrow blasts cells in Burkitt lymphoma/leukemia (BL) are L3 morphology, mature immunophenotype of blasts with surface IgM expression, and presence of typical MYC gene rearrangements.The aim of the study was to show discrepancy examples in laboratory signs of BL.Patients and methods. 10 patients (8 boys and 2 girls) aged 1 to 18 years were included in the present study. The inclusion criterion was the identification of discrepancies between flow cytometric, morphological and cytogenetic data.Results. In 2 cases there were no rearrangements of the MYC gene. In 2 patients, the L2 morphological variant went against the presence of typical MYC gene rearrangements. In one case, undifferentiated blasts cells were described by morphology together with presence of surface IgM, and atypical genetics. In 8 patients, there was no expression of surface IgM. Of these, patients with absence of cytomorphological data cytometric and genetic data were controversial.Сonclusion. The cases presented in this study and the cases described in the literature demonstrate the importance of an attentive and comprehensive approach in evaluating the results of laboratory tests in the diagnosis of BL. |
| format | Article |
| id | doaj-art-4130c991b9de46b287bc2bc5e336bf65 |
| institution | Matheson Library |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2018-10-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-4130c991b9de46b287bc2bc5e336bf652025-08-04T13:57:50ZrusABV-pressОнкогематология1818-83462413-40232018-10-01133768210.17650/1818-8346-2018-13-3-76-82282Rare cases of laboratory tests discrepancies in diagnostics of pediatric Burkitt lymphoma/leukemiaI. A. Demina0O. I. Illarionova11T. Yu. Verzhbitskaya2G. A. Tsaur3E. B. Rusanova4M. V. Gorchakova5E. E. Zueva6M. B. Belogurova7G. I. Uleiskaya8L. A. Shchekina9A. N. Kazakova10E. A. Zerkalenkova11Yu. V. Olshanskaya12Yu. G. Abugova13l. G. Fechina14N. V. Miakova15E. V. Samochatova16A. A. Maschan17A. M. Popov18Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia.Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia.Sverdlovsk Regional Clinical Children’s Hospital No 1; Research Institute of Medical Cell Technologies.Sverdlovsk Regional Clinical Children’s Hospital No 1; Research Institute of Medical Cell Technologies.I.P. Pavlov First Saint Petersburg State Medical University.I.P. Pavlov First Saint Petersburg State Medical University.I.P. Pavlov First Saint Petersburg State Medical University; Ariel University, Faculty of Natural Sciences, Department of Molecular Biology.St. Petersburg Clinical Scientific and Practical Center of Specialized Medical Assistance (Oncological).City Clinical Hospital No. 31.City Clinical Hospital No. 31.Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia.Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia.Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia.Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia.Sverdlovsk Regional Clinical Children’s Hospital No 1.; Research Institute of Medical Cell Technologies.Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia.Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia.Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia.Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia.Introduction. The main features of bone marrow blasts cells in Burkitt lymphoma/leukemia (BL) are L3 morphology, mature immunophenotype of blasts with surface IgM expression, and presence of typical MYC gene rearrangements.The aim of the study was to show discrepancy examples in laboratory signs of BL.Patients and methods. 10 patients (8 boys and 2 girls) aged 1 to 18 years were included in the present study. The inclusion criterion was the identification of discrepancies between flow cytometric, morphological and cytogenetic data.Results. In 2 cases there were no rearrangements of the MYC gene. In 2 patients, the L2 morphological variant went against the presence of typical MYC gene rearrangements. In one case, undifferentiated blasts cells were described by morphology together with presence of surface IgM, and atypical genetics. In 8 patients, there was no expression of surface IgM. Of these, patients with absence of cytomorphological data cytometric and genetic data were controversial.Сonclusion. The cases presented in this study and the cases described in the literature demonstrate the importance of an attentive and comprehensive approach in evaluating the results of laboratory tests in the diagnosis of BL.https://oncohematology.abvpress.ru/ongm/article/view/309сonclusion. the cases presented in this study and the cases described in the literature demonstrate the importance of an attentive and comprehensive approach in evaluating the results of laboratory tests in the diagnosis of bl. |
| spellingShingle | I. A. Demina O. I. Illarionova1 T. Yu. Verzhbitskaya G. A. Tsaur E. B. Rusanova M. V. Gorchakova E. E. Zueva M. B. Belogurova G. I. Uleiskaya L. A. Shchekina A. N. Kazakova E. A. Zerkalenkova Yu. V. Olshanskaya Yu. G. Abugova l. G. Fechina N. V. Miakova E. V. Samochatova A. A. Maschan A. M. Popov Rare cases of laboratory tests discrepancies in diagnostics of pediatric Burkitt lymphoma/leukemia Онкогематология сonclusion. the cases presented in this study and the cases described in the literature demonstrate the importance of an attentive and comprehensive approach in evaluating the results of laboratory tests in the diagnosis of bl. |
| title | Rare cases of laboratory tests discrepancies in diagnostics of pediatric Burkitt lymphoma/leukemia |
| title_full | Rare cases of laboratory tests discrepancies in diagnostics of pediatric Burkitt lymphoma/leukemia |
| title_fullStr | Rare cases of laboratory tests discrepancies in diagnostics of pediatric Burkitt lymphoma/leukemia |
| title_full_unstemmed | Rare cases of laboratory tests discrepancies in diagnostics of pediatric Burkitt lymphoma/leukemia |
| title_short | Rare cases of laboratory tests discrepancies in diagnostics of pediatric Burkitt lymphoma/leukemia |
| title_sort | rare cases of laboratory tests discrepancies in diagnostics of pediatric burkitt lymphoma leukemia |
| topic | сonclusion. the cases presented in this study and the cases described in the literature demonstrate the importance of an attentive and comprehensive approach in evaluating the results of laboratory tests in the diagnosis of bl. |
| url | https://oncohematology.abvpress.ru/ongm/article/view/309 |
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