POSSIBLE CHANGES IN THE CENTRAL HEMODYNAMICS IN PORTAL HYPERTENSION DUE TO LIVER CIRRHOSIS OF VIRAL ETIOLOGY WITH DIFFERENT LEVELS OF CYTOKINES
Aim. To study possible variants of changes in structural and functional parameters of central hemodynamics in liver cirrhosis classes A, B, C (Child– Pugh) to improve the early diagnostics of extrahepatic complications.Material and methods. Parameters of central hemodynamics were studied in 107 pati...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Столичная издательская компания
2017-01-01
|
| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/1371 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839641261854687232 |
|---|---|
| author | V. E Kulikov T. A. Emelina O. G. Kazakova K. V. Nikolaevа M. E. Hapman M. A. Tonеeva |
| author_facet | V. E Kulikov T. A. Emelina O. G. Kazakova K. V. Nikolaevа M. E. Hapman M. A. Tonеeva |
| author_sort | V. E Kulikov |
| collection | DOAJ |
| description | Aim. To study possible variants of changes in structural and functional parameters of central hemodynamics in liver cirrhosis classes A, B, C (Child– Pugh) to improve the early diagnostics of extrahepatic complications.Material and methods. Parameters of central hemodynamics were studied in 107 patients with liver cirrhosis of viral etiology classes A, B, C (ChildPugh) with different levels of serum interleukins (interleukin-2, interleukin-6, tumor necrosis factor alpha).Results. Significant changes in the central hemodynamics parameters were not revealed in liver cirrhosis of classes A and B. In patients with liver cirrhosis of class С the following significant changes of the left and right heart were found: thickening of the interventricular septum and left ventricular posterior wall up to 12.9Ѓ}1.3 and 13.5Ѓ}1.4 mm respectively; increase in left atrium up to 43.1Ѓ}4.7 mm; right ventricular dilatation up to 38.6Ѓ}4.1 mm and pulmonary artery up to 35.7Ѓ}3.1 mm with an increase in pressure in it up to 35.7Ѓ}3.1 mm Hg. The rate and variants of changes in structural and functional parameters of central hemodynamics correlated with the stages of the liver cirrhosis compensation and the interleukins serum levels.Conclusion. Changes in parameters of central hemodynamics in liver cirrhosis depends on the stage of compensation. The most pronounced systolic and diastolic myocardial dysfunctions were observed in cirrhosis Class C, with high levels of portal pressure and high concentrations of serum interleukins. Concentric remodeling of the left ventricular and isolated ventricular septal hypertrophy were the worst types of the left ventricular remodeling. These variants of ventricular geometry were accompanied by the most severe impairments of diastolic function. |
| format | Article |
| id | doaj-art-40c21a40b6de43f9ab1f286d75d6c082 |
| institution | Matheson Library |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-40c21a40b6de43f9ab1f286d75d6c0822025-07-03T07:28:32ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532017-01-0112668569110.20996/1819-6446-2016-12-6-685-6911283POSSIBLE CHANGES IN THE CENTRAL HEMODYNAMICS IN PORTAL HYPERTENSION DUE TO LIVER CIRRHOSIS OF VIRAL ETIOLOGY WITH DIFFERENT LEVELS OF CYTOKINESV. E Kulikov0T. A. Emelina1O. G. Kazakova2K. V. Nikolaevа3M. E. Hapman4M. A. Tonеeva5Ulyanovsk State UniversityUlyanovsk State UniversityUlyanovsk State UniversityUlyanovsk State UniversityUlyanovsk State UniversityUlyanovsk State UniversityAim. To study possible variants of changes in structural and functional parameters of central hemodynamics in liver cirrhosis classes A, B, C (Child– Pugh) to improve the early diagnostics of extrahepatic complications.Material and methods. Parameters of central hemodynamics were studied in 107 patients with liver cirrhosis of viral etiology classes A, B, C (ChildPugh) with different levels of serum interleukins (interleukin-2, interleukin-6, tumor necrosis factor alpha).Results. Significant changes in the central hemodynamics parameters were not revealed in liver cirrhosis of classes A and B. In patients with liver cirrhosis of class С the following significant changes of the left and right heart were found: thickening of the interventricular septum and left ventricular posterior wall up to 12.9Ѓ}1.3 and 13.5Ѓ}1.4 mm respectively; increase in left atrium up to 43.1Ѓ}4.7 mm; right ventricular dilatation up to 38.6Ѓ}4.1 mm and pulmonary artery up to 35.7Ѓ}3.1 mm with an increase in pressure in it up to 35.7Ѓ}3.1 mm Hg. The rate and variants of changes in structural and functional parameters of central hemodynamics correlated with the stages of the liver cirrhosis compensation and the interleukins serum levels.Conclusion. Changes in parameters of central hemodynamics in liver cirrhosis depends on the stage of compensation. The most pronounced systolic and diastolic myocardial dysfunctions were observed in cirrhosis Class C, with high levels of portal pressure and high concentrations of serum interleukins. Concentric remodeling of the left ventricular and isolated ventricular septal hypertrophy were the worst types of the left ventricular remodeling. These variants of ventricular geometry were accompanied by the most severe impairments of diastolic function.https://www.rpcardio.online/jour/article/view/1371liver cirrhosiscentral hemodynamicsinterleukin-2interleukin-6tumor necrosis factor alpha. |
| spellingShingle | V. E Kulikov T. A. Emelina O. G. Kazakova K. V. Nikolaevа M. E. Hapman M. A. Tonеeva POSSIBLE CHANGES IN THE CENTRAL HEMODYNAMICS IN PORTAL HYPERTENSION DUE TO LIVER CIRRHOSIS OF VIRAL ETIOLOGY WITH DIFFERENT LEVELS OF CYTOKINES Рациональная фармакотерапия в кардиологии liver cirrhosis central hemodynamics interleukin-2 interleukin-6 tumor necrosis factor alpha. |
| title | POSSIBLE CHANGES IN THE CENTRAL HEMODYNAMICS IN PORTAL HYPERTENSION DUE TO LIVER CIRRHOSIS OF VIRAL ETIOLOGY WITH DIFFERENT LEVELS OF CYTOKINES |
| title_full | POSSIBLE CHANGES IN THE CENTRAL HEMODYNAMICS IN PORTAL HYPERTENSION DUE TO LIVER CIRRHOSIS OF VIRAL ETIOLOGY WITH DIFFERENT LEVELS OF CYTOKINES |
| title_fullStr | POSSIBLE CHANGES IN THE CENTRAL HEMODYNAMICS IN PORTAL HYPERTENSION DUE TO LIVER CIRRHOSIS OF VIRAL ETIOLOGY WITH DIFFERENT LEVELS OF CYTOKINES |
| title_full_unstemmed | POSSIBLE CHANGES IN THE CENTRAL HEMODYNAMICS IN PORTAL HYPERTENSION DUE TO LIVER CIRRHOSIS OF VIRAL ETIOLOGY WITH DIFFERENT LEVELS OF CYTOKINES |
| title_short | POSSIBLE CHANGES IN THE CENTRAL HEMODYNAMICS IN PORTAL HYPERTENSION DUE TO LIVER CIRRHOSIS OF VIRAL ETIOLOGY WITH DIFFERENT LEVELS OF CYTOKINES |
| title_sort | possible changes in the central hemodynamics in portal hypertension due to liver cirrhosis of viral etiology with different levels of cytokines |
| topic | liver cirrhosis central hemodynamics interleukin-2 interleukin-6 tumor necrosis factor alpha. |
| url | https://www.rpcardio.online/jour/article/view/1371 |
| work_keys_str_mv | AT vekulikov possiblechangesinthecentralhemodynamicsinportalhypertensionduetolivercirrhosisofviraletiologywithdifferentlevelsofcytokines AT taemelina possiblechangesinthecentralhemodynamicsinportalhypertensionduetolivercirrhosisofviraletiologywithdifferentlevelsofcytokines AT ogkazakova possiblechangesinthecentralhemodynamicsinportalhypertensionduetolivercirrhosisofviraletiologywithdifferentlevelsofcytokines AT kvnikolaeva possiblechangesinthecentralhemodynamicsinportalhypertensionduetolivercirrhosisofviraletiologywithdifferentlevelsofcytokines AT mehapman possiblechangesinthecentralhemodynamicsinportalhypertensionduetolivercirrhosisofviraletiologywithdifferentlevelsofcytokines AT matoneeva possiblechangesinthecentralhemodynamicsinportalhypertensionduetolivercirrhosisofviraletiologywithdifferentlevelsofcytokines |