Hydrolysates from a Whey Protein Concentrate Are a Promising Functional Ingredient for Diabetes Control via DPP-IV Inhibition
The circular economy has been a strategy for diminishing waste and improving the use of natural resources and energy in different industrial sectors. The food industry is a manufacturing and service sector with few incorporations into sustainable development from the circular economy philosophy due...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Series: | Biology and Life Sciences Forum |
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| Online Access: | https://www.mdpi.com/2673-9976/40/1/10 |
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| author | Selene Isabel Alvarez-Chávez Itzury Reyes-Ramírez Luis Guillermo González-Olivares Jesús Guadalupe Pérez-Flores Elizabeth Contreras-López Laura Berenice Olvera-Rosales Laura García-Curiel Emmanuel Pérez-Escalante |
| author_facet | Selene Isabel Alvarez-Chávez Itzury Reyes-Ramírez Luis Guillermo González-Olivares Jesús Guadalupe Pérez-Flores Elizabeth Contreras-López Laura Berenice Olvera-Rosales Laura García-Curiel Emmanuel Pérez-Escalante |
| author_sort | Selene Isabel Alvarez-Chávez |
| collection | DOAJ |
| description | The circular economy has been a strategy for diminishing waste and improving the use of natural resources and energy in different industrial sectors. The food industry is a manufacturing and service sector with few incorporations into sustainable development from the circular economy philosophy due to the absence of concrete or real scenarios to be carried out. The dairy industry has incorporated some strategies to mitigate the contamination, producing whey concentrate powders and their hydrolysates as alternatives. Thus, the work aimed to produce hydrolysates with antidiabetic functions from the hydrolysis with alcalase and flavourzyme of whey protein concentrate with 80% protein. Dispersions of whey powder were prepared in phosphate buffer at pH = 7.5 and hydrolyzed for 6 h at 60 °C and 130 rpm. The hydrolysates produced maintained an antidiabetic activity between 43% and 52% from dipeptidyl peptidase IV (DPP-IV) inhibition, with the alcalase enzyme slightly better. Thus, the enzymatic process tested on whey protein concentrate generated a promising ingredient for glycemic control. |
| format | Article |
| id | doaj-art-3f935e8242914a66a60b67a29f656c3c |
| institution | Matheson Library |
| issn | 2673-9976 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology and Life Sciences Forum |
| spelling | doaj-art-3f935e8242914a66a60b67a29f656c3c2025-06-25T13:34:41ZengMDPI AGBiology and Life Sciences Forum2673-99762025-01-014011010.3390/blsf2024040010Hydrolysates from a Whey Protein Concentrate Are a Promising Functional Ingredient for Diabetes Control via DPP-IV InhibitionSelene Isabel Alvarez-Chávez0Itzury Reyes-Ramírez1Luis Guillermo González-Olivares2Jesús Guadalupe Pérez-Flores3Elizabeth Contreras-López4Laura Berenice Olvera-Rosales5Laura García-Curiel6Emmanuel Pérez-Escalante7Área Académica de Química, Universidad Autónoma del Estado de Hidalgo, Carretera Pachuca-Tulancingo km. 4.5, Ciudad del Conocimiento, Mineral de la Reforma 42184, MexicoÁrea Académica de Química, Universidad Autónoma del Estado de Hidalgo, Carretera Pachuca-Tulancingo km. 4.5, Ciudad del Conocimiento, Mineral de la Reforma 42184, MexicoÁrea Académica de Química, Universidad Autónoma del Estado de Hidalgo, Carretera Pachuca-Tulancingo km. 4.5, Ciudad del Conocimiento, Mineral de la Reforma 42184, MexicoÁrea Académica de Química, Universidad Autónoma del Estado de Hidalgo, Carretera Pachuca-Tulancingo km. 4.5, Ciudad del Conocimiento, Mineral de la Reforma 42184, MexicoÁrea Académica de Química, Universidad Autónoma del Estado de Hidalgo, Carretera Pachuca-Tulancingo km. 4.5, Ciudad del Conocimiento, Mineral de la Reforma 42184, MexicoÁrea Académica de Química, Universidad Autónoma del Estado de Hidalgo, Carretera Pachuca-Tulancingo km. 4.5, Ciudad del Conocimiento, Mineral de la Reforma 42184, MexicoÁrea Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Carretera Pachuca-Actopan Camino a Tilcuautla s/n, San Agustín Tlaxiaca 42060, MexicoÁrea Académica de Química, Universidad Autónoma del Estado de Hidalgo, Carretera Pachuca-Tulancingo km. 4.5, Ciudad del Conocimiento, Mineral de la Reforma 42184, MexicoThe circular economy has been a strategy for diminishing waste and improving the use of natural resources and energy in different industrial sectors. The food industry is a manufacturing and service sector with few incorporations into sustainable development from the circular economy philosophy due to the absence of concrete or real scenarios to be carried out. The dairy industry has incorporated some strategies to mitigate the contamination, producing whey concentrate powders and their hydrolysates as alternatives. Thus, the work aimed to produce hydrolysates with antidiabetic functions from the hydrolysis with alcalase and flavourzyme of whey protein concentrate with 80% protein. Dispersions of whey powder were prepared in phosphate buffer at pH = 7.5 and hydrolyzed for 6 h at 60 °C and 130 rpm. The hydrolysates produced maintained an antidiabetic activity between 43% and 52% from dipeptidyl peptidase IV (DPP-IV) inhibition, with the alcalase enzyme slightly better. Thus, the enzymatic process tested on whey protein concentrate generated a promising ingredient for glycemic control.https://www.mdpi.com/2673-9976/40/1/10bovine whey powderwhey contamination mitigationenzymatic hydrolysisantidiabetic peptides |
| spellingShingle | Selene Isabel Alvarez-Chávez Itzury Reyes-Ramírez Luis Guillermo González-Olivares Jesús Guadalupe Pérez-Flores Elizabeth Contreras-López Laura Berenice Olvera-Rosales Laura García-Curiel Emmanuel Pérez-Escalante Hydrolysates from a Whey Protein Concentrate Are a Promising Functional Ingredient for Diabetes Control via DPP-IV Inhibition Biology and Life Sciences Forum bovine whey powder whey contamination mitigation enzymatic hydrolysis antidiabetic peptides |
| title | Hydrolysates from a Whey Protein Concentrate Are a Promising Functional Ingredient for Diabetes Control via DPP-IV Inhibition |
| title_full | Hydrolysates from a Whey Protein Concentrate Are a Promising Functional Ingredient for Diabetes Control via DPP-IV Inhibition |
| title_fullStr | Hydrolysates from a Whey Protein Concentrate Are a Promising Functional Ingredient for Diabetes Control via DPP-IV Inhibition |
| title_full_unstemmed | Hydrolysates from a Whey Protein Concentrate Are a Promising Functional Ingredient for Diabetes Control via DPP-IV Inhibition |
| title_short | Hydrolysates from a Whey Protein Concentrate Are a Promising Functional Ingredient for Diabetes Control via DPP-IV Inhibition |
| title_sort | hydrolysates from a whey protein concentrate are a promising functional ingredient for diabetes control via dpp iv inhibition |
| topic | bovine whey powder whey contamination mitigation enzymatic hydrolysis antidiabetic peptides |
| url | https://www.mdpi.com/2673-9976/40/1/10 |
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