Hexosamine biosynthesis disruption impairs GPI production and arrests Plasmodium falciparum growth at schizont stages.
UDP-N-acetylglucosamine (UDP-GlcNAc) is a crucial sugar nucleotide for glycan synthesis in eukaryotes. In the malaria parasite Plasmodium falciparum, UDP-GlcNAc is synthesized via the hexosamine biosynthetic pathway (HBP) and is essential for glycosylphosphatidylinositol (GPI) anchor production, the...
Bewaard in:
| Hoofdauteurs: | , , , , , , , , , , |
|---|---|
| Formaat: | Artikel |
| Taal: | Engels |
| Gepubliceerd in: |
Public Library of Science (PLoS)
2025-07-01
|
| Reeks: | PLoS Pathogens |
| Online toegang: | https://doi.org/10.1371/journal.ppat.1012832 |
| Tags: |
Voeg label toe
Geen labels, Wees de eerste die dit record labelt!
|