Immunobiological Properties of <i>Francisella tularensis</i> 15/10 Strain with Deleted recA Gene
Deletion of recA gene in Francisella tularensis 15/10 genome leads to the increase in its sensitivity to ultraviolet irradiation, reduction of the homologous recombination capacity, and a slight decline of virulence for mice. Efficacy of Francisella tularensis 15/10ΔrecA reproduction within micropha...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2011-08-01
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| Series: | Проблемы особо опасных инфекций |
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| Online Access: | https://journal.microbe.ru/jour/article/view/707 |
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| author | A. A. Lapin A. N. Mokrievich G. M. Vakhrameeva T. I. Kombarova I. V. Bakhteeva I. A. Dyatlov V. M. Pavlov |
| author_facet | A. A. Lapin A. N. Mokrievich G. M. Vakhrameeva T. I. Kombarova I. V. Bakhteeva I. A. Dyatlov V. M. Pavlov |
| author_sort | A. A. Lapin |
| collection | DOAJ |
| description | Deletion of recA gene in Francisella tularensis 15/10 genome leads to the increase in its sensitivity to ultraviolet irradiation, reduction of the homologous recombination capacity, and a slight decline of virulence for mice. Efficacy of Francisella tularensis 15/10ΔrecA reproduction within microphage-like cells, its resistance to normal rabbit serum, and protective properties on the mouse model of tularemia are the same as in original Francisella tularensis 15/10. |
| format | Article |
| id | doaj-art-3eeddc45830c48d6bb4a5b9e4de400c1 |
| institution | Matheson Library |
| issn | 0370-1069 2658-719X |
| language | Russian |
| publishDate | 2011-08-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| series | Проблемы особо опасных инфекций |
| spelling | doaj-art-3eeddc45830c48d6bb4a5b9e4de400c12025-07-07T08:02:35ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2011-08-0104(110)656710.21055/0370-1069-2011-4(110)-65-67691Immunobiological Properties of <i>Francisella tularensis</i> 15/10 Strain with Deleted recA GeneA. A. Lapin0A. N. Mokrievich1G. M. Vakhrameeva2T. I. Kombarova3I. V. Bakhteeva4I. A. Dyatlov5V. M. Pavlov6State Research Center of Applied Microbiology and BiotechnologyState Research Center of Applied Microbiology and BiotechnologyState Research Center of Applied Microbiology and BiotechnologyState Research Center of Applied Microbiology and BiotechnologyState Research Center of Applied Microbiology and BiotechnologyState Research Center of Applied Microbiology and BiotechnologyState Research Center of Applied Microbiology and BiotechnologyDeletion of recA gene in Francisella tularensis 15/10 genome leads to the increase in its sensitivity to ultraviolet irradiation, reduction of the homologous recombination capacity, and a slight decline of virulence for mice. Efficacy of Francisella tularensis 15/10ΔrecA reproduction within microphage-like cells, its resistance to normal rabbit serum, and protective properties on the mouse model of tularemia are the same as in original Francisella tularensis 15/10.https://journal.microbe.ru/jour/article/view/707tularemia vaccine strain<i>reca </i>generecombinationprotective properties |
| spellingShingle | A. A. Lapin A. N. Mokrievich G. M. Vakhrameeva T. I. Kombarova I. V. Bakhteeva I. A. Dyatlov V. M. Pavlov Immunobiological Properties of <i>Francisella tularensis</i> 15/10 Strain with Deleted recA Gene Проблемы особо опасных инфекций tularemia vaccine strain <i>reca </i>gene recombination protective properties |
| title | Immunobiological Properties of <i>Francisella tularensis</i> 15/10 Strain with Deleted recA Gene |
| title_full | Immunobiological Properties of <i>Francisella tularensis</i> 15/10 Strain with Deleted recA Gene |
| title_fullStr | Immunobiological Properties of <i>Francisella tularensis</i> 15/10 Strain with Deleted recA Gene |
| title_full_unstemmed | Immunobiological Properties of <i>Francisella tularensis</i> 15/10 Strain with Deleted recA Gene |
| title_short | Immunobiological Properties of <i>Francisella tularensis</i> 15/10 Strain with Deleted recA Gene |
| title_sort | immunobiological properties of i francisella tularensis i 15 10 strain with deleted reca gene |
| topic | tularemia vaccine strain <i>reca </i>gene recombination protective properties |
| url | https://journal.microbe.ru/jour/article/view/707 |
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