Treatment of epilepsy associated with primary and metastatic brain tumors
There is a number of unsolved issues in management of epilepsy associated with primary and metastatic brain tumors (BTs). In particular, no consensus approaches to treatment of patients with epilepsy associated with BTs have been proposed regarding use of current anti-epileptic drugs (AEDs). The rev...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2021-10-01
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| Series: | Эпилепсия и пароксизмальные состояния |
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| Online Access: | https://www.epilepsia.su/jour/article/view/733 |
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| author | A V. Lebedeva S. G. Burd P. N. Vlasov N. A. Ermolenko I. A. Zhidkova S. K. Zyryanov I. Yu. Kovaleva D. R. Naskhletashvili N. Yu. Perunova I. G. Rudakova R. K. Shikhkerimov M. A. Yamin |
| author_facet | A V. Lebedeva S. G. Burd P. N. Vlasov N. A. Ermolenko I. A. Zhidkova S. K. Zyryanov I. Yu. Kovaleva D. R. Naskhletashvili N. Yu. Perunova I. G. Rudakova R. K. Shikhkerimov M. A. Yamin |
| author_sort | A V. Lebedeva |
| collection | DOAJ |
| description | There is a number of unsolved issues in management of epilepsy associated with primary and metastatic brain tumors (BTs). In particular, no consensus approaches to treatment of patients with epilepsy associated with BTs have been proposed regarding use of current anti-epileptic drugs (AEDs). The review presents the relevant data on epidemiology, features of clinically manifested epilepsy at varying stages of BTs, aspects of drug-drug interaction between AEDs and anti-tumor agents, AED-related effects on cognitive functions as well as quality of life in patients with epilepsy associated with BTs. Levetiracetam and valproic acid comprise the first-line drugs for treating seizures in patients with BTs. It is unreasonable to use AEDs acting as hepatic microsomal enzyme inducers for therapy of epileptic seizures in BTs, because it may decrease efficacy of chemotherapy agents and glucocorticoids along with elevated rate of side effects. Perampanel acting as a selective noncompetitive AMPA receptor antagonist, may be one of the drugs of choice for the adjunctive therapy of epileptic seizures associated with BTs. |
| format | Article |
| id | doaj-art-3ea53ba9acdf4f9d89b3ae4c20b24ea1 |
| institution | Matheson Library |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| publishDate | 2021-10-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj-art-3ea53ba9acdf4f9d89b3ae4c20b24ea12025-08-03T19:51:22ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882021-10-0113328630410.17749/2077-8333/epi.par.con.2021.099553Treatment of epilepsy associated with primary and metastatic brain tumorsA V. Lebedeva0S. G. Burd1P. N. Vlasov2N. A. Ermolenko3I. A. Zhidkova4S. K. Zyryanov5I. Yu. Kovaleva6D. R. Naskhletashvili7N. Yu. Perunova8I. G. Rudakova9R. K. Shikhkerimov10M. A. Yamin11Pirogov Russian National Research Medical University; Research Institute of Healthcare Organization and Medical ManagementPirogov Russian National Research Medical University; Federal Center for Brain and NeurotechnologyYevdokimov Moscow State University of Medicine and DentistryBurdenko Voronezh State Medical University; Voronezh Regional Children's Clinical Hospital No. 1Yevdokimov Moscow State University of Medicine and DentistryPeoples’ Friendship University of Russia; City Clinical Hospital No. 24Pirogov Russian National Research Medical UniversityBlokhin National Medical Research Center of OncologyMedical Center "NeurologyVladimirskiy Moscow Regional Research Clinical InstitutePolyclinic No. 4, Department of Affairs of the President of the Russian Federation; City Polyclinic No. 166Regional Consultative and Diagnostic Center; Rostov State Medical UniversityThere is a number of unsolved issues in management of epilepsy associated with primary and metastatic brain tumors (BTs). In particular, no consensus approaches to treatment of patients with epilepsy associated with BTs have been proposed regarding use of current anti-epileptic drugs (AEDs). The review presents the relevant data on epidemiology, features of clinically manifested epilepsy at varying stages of BTs, aspects of drug-drug interaction between AEDs and anti-tumor agents, AED-related effects on cognitive functions as well as quality of life in patients with epilepsy associated with BTs. Levetiracetam and valproic acid comprise the first-line drugs for treating seizures in patients with BTs. It is unreasonable to use AEDs acting as hepatic microsomal enzyme inducers for therapy of epileptic seizures in BTs, because it may decrease efficacy of chemotherapy agents and glucocorticoids along with elevated rate of side effects. Perampanel acting as a selective noncompetitive AMPA receptor antagonist, may be one of the drugs of choice for the adjunctive therapy of epileptic seizures associated with BTs.https://www.epilepsia.su/jour/article/view/733epilepsyconvulsive syndromecerebral tumorbtcancermanagement featuresperampanelquality of life |
| spellingShingle | A V. Lebedeva S. G. Burd P. N. Vlasov N. A. Ermolenko I. A. Zhidkova S. K. Zyryanov I. Yu. Kovaleva D. R. Naskhletashvili N. Yu. Perunova I. G. Rudakova R. K. Shikhkerimov M. A. Yamin Treatment of epilepsy associated with primary and metastatic brain tumors Эпилепсия и пароксизмальные состояния epilepsy convulsive syndrome cerebral tumor bt cancer management features perampanel quality of life |
| title | Treatment of epilepsy associated with primary and metastatic brain tumors |
| title_full | Treatment of epilepsy associated with primary and metastatic brain tumors |
| title_fullStr | Treatment of epilepsy associated with primary and metastatic brain tumors |
| title_full_unstemmed | Treatment of epilepsy associated with primary and metastatic brain tumors |
| title_short | Treatment of epilepsy associated with primary and metastatic brain tumors |
| title_sort | treatment of epilepsy associated with primary and metastatic brain tumors |
| topic | epilepsy convulsive syndrome cerebral tumor bt cancer management features perampanel quality of life |
| url | https://www.epilepsia.su/jour/article/view/733 |
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