Recent progress in the study of exosomes in the gastric cancer immune microenvironment
Gastric cancer (GC) ranks among the most prevalent forms of cancer and contributes significantly to cancer-related mortality. There exists a pressing need to investigate novel approaches for GC management to improve diagnostic methods, therapeutic interventions, and patient outcomes. Exosomes are na...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1595124/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839619489720696832 |
|---|---|
| author | Haibo Liu Lei Zhu Jianmei Yin |
| author_facet | Haibo Liu Lei Zhu Jianmei Yin |
| author_sort | Haibo Liu |
| collection | DOAJ |
| description | Gastric cancer (GC) ranks among the most prevalent forms of cancer and contributes significantly to cancer-related mortality. There exists a pressing need to investigate novel approaches for GC management to improve diagnostic methods, therapeutic interventions, and patient outcomes. Exosomes are nanoscale extracellular vesicles (EVs) derived from various cell types that carry a diverse range of biomolecular cargo, including DNA, RNA, proteins, lipids, and other bioactive constituents. They play significant roles in GC pathogenesis and tumor microenvironment (TME) modulation. Exosomes derived from cancer cells can enhance tumor progression, transform the TME, and modulate immune responses. Immune cell-derived exosomes can similarly modulate immune functions and the TME. Immunotherapy represents a GC treatment breakthrough and is expected to show efficacy when combined with exosome-targeted therapy. Abundant research has demonstrated that exosomes are crucial for tumor growth, immune evasion, immune microenvironment reconfiguration, and immunotherapy efficacy in GC. This review describes the role of exosomes in the GC microenvironment, focusing on the mechanisms by which exosomes regulate immune responses to GC, and summarizes the current status of and challenges in the development of exosome-based diagnostics and immunotherapy for GC. |
| format | Article |
| id | doaj-art-3e87c88fe1fa4a8c8f11bc38ab5e915f |
| institution | Matheson Library |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-3e87c88fe1fa4a8c8f11bc38ab5e915f2025-07-23T05:35:47ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-07-011610.3389/fimmu.2025.15951241595124Recent progress in the study of exosomes in the gastric cancer immune microenvironmentHaibo Liu0Lei Zhu1Jianmei Yin2Emergency Department, The First Hospital of Jilin University, Changchun, Jilin, ChinaEmergency Department, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Otolaryngology-Head and Neck Surgery, The First Hospital of Jilin University, Changchun, Jilin, ChinaGastric cancer (GC) ranks among the most prevalent forms of cancer and contributes significantly to cancer-related mortality. There exists a pressing need to investigate novel approaches for GC management to improve diagnostic methods, therapeutic interventions, and patient outcomes. Exosomes are nanoscale extracellular vesicles (EVs) derived from various cell types that carry a diverse range of biomolecular cargo, including DNA, RNA, proteins, lipids, and other bioactive constituents. They play significant roles in GC pathogenesis and tumor microenvironment (TME) modulation. Exosomes derived from cancer cells can enhance tumor progression, transform the TME, and modulate immune responses. Immune cell-derived exosomes can similarly modulate immune functions and the TME. Immunotherapy represents a GC treatment breakthrough and is expected to show efficacy when combined with exosome-targeted therapy. Abundant research has demonstrated that exosomes are crucial for tumor growth, immune evasion, immune microenvironment reconfiguration, and immunotherapy efficacy in GC. This review describes the role of exosomes in the GC microenvironment, focusing on the mechanisms by which exosomes regulate immune responses to GC, and summarizes the current status of and challenges in the development of exosome-based diagnostics and immunotherapy for GC.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1595124/fullgastric cancerexosomesimmunitytumor microenvironmenttumor immunotherapy |
| spellingShingle | Haibo Liu Lei Zhu Jianmei Yin Recent progress in the study of exosomes in the gastric cancer immune microenvironment Frontiers in Immunology gastric cancer exosomes immunity tumor microenvironment tumor immunotherapy |
| title | Recent progress in the study of exosomes in the gastric cancer immune microenvironment |
| title_full | Recent progress in the study of exosomes in the gastric cancer immune microenvironment |
| title_fullStr | Recent progress in the study of exosomes in the gastric cancer immune microenvironment |
| title_full_unstemmed | Recent progress in the study of exosomes in the gastric cancer immune microenvironment |
| title_short | Recent progress in the study of exosomes in the gastric cancer immune microenvironment |
| title_sort | recent progress in the study of exosomes in the gastric cancer immune microenvironment |
| topic | gastric cancer exosomes immunity tumor microenvironment tumor immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1595124/full |
| work_keys_str_mv | AT haiboliu recentprogressinthestudyofexosomesinthegastriccancerimmunemicroenvironment AT leizhu recentprogressinthestudyofexosomesinthegastriccancerimmunemicroenvironment AT jianmeiyin recentprogressinthestudyofexosomesinthegastriccancerimmunemicroenvironment |