The effect of complex pharmacotherapy regimens using a herbal remedy from <i>Hippophae rhamnoides</i> on biochemical blood parameters of rats with paracetamol hepatitis
Background. The use of complexes of synthetic and herbal remedies as hepatoprotectors in the treatment of liver pathologies of various etiologies is an urgent task of pharmacology. A promising type of medicinal plant raw material is an extract of Hippophaes rhamnoides leaves. The hepatoprotective...
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Scientific Сentre for Family Health and Human Reproduction Problems
2024-01-01
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| Series: | Acta Biomedica Scientifica |
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| Online Access: | https://www.actabiomedica.ru/jour/article/view/4511 |
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| author | S. Yu. Batueva G. P. Lamazhapova Yu. A. Kapustina O. A. Rodnaeva S. A. Chukaev |
| author_facet | S. Yu. Batueva G. P. Lamazhapova Yu. A. Kapustina O. A. Rodnaeva S. A. Chukaev |
| author_sort | S. Yu. Batueva |
| collection | DOAJ |
| description | Background. The use of complexes of synthetic and herbal remedies as hepatoprotectors in the treatment of liver pathologies of various etiologies is an urgent task of pharmacology. A promising type of medicinal plant raw material is an extract of Hippophaes rhamnoides leaves. The hepatoprotective effect of extract of Hippophaes rhamnoides leaves in combination with ademethionine has not been studied to date.The aim of the research was to study changes in biochemical markers of hepatic function in the application of complex schemes of pharmacotherapy of experimental liver damage with paracetamol using Extractum foliorum Hippophaes rhamnoides.Materials and methods. The experimental study was performed on Wistar rats, the animals were divided into six groups. Group 1 (intact) – animals without a model of liver damage and without treatment; in Group 2 (control) paracetamol was used to create experimental hepatitis without treatment (positive control group); in Group 3 (comparison) a combination of “silibinin + ademethionine” was used on a model of paracetamol hepatitis; in Group 4 (experimental) extract of Hippophaes rhamnoides leaves was used on the model of paracetamol hepatitis; in Group 5 (experimental) ademethionine was used on a model of paracetamol hepatitis; in Group 6 (experimental) a combination of extract of Hippophaes rhamnoides leaves and ademethionine was used on a model of paracetamol hepatitis. The functional state of the liver of experimental animals was determined by biochemical parameters.Results. When using a combination of extract of Hippophaes rhamnoides leaves with ademethionine, the studied biochemical parameters significantly (p < 0.05) differed from the numerical values in the negative control group and were closest to those in the intact group than in other experimental groups.Conclusions. A comparison of the effectiveness of the use of extract of Hippophaes rhamnoides leaves in combination with ademethionine by the total effect on blood biochemical parameters determines this complex as a promising drug for further research. |
| format | Article |
| id | doaj-art-3c5840d9a2964a6bb55f7e008d42f4b3 |
| institution | Matheson Library |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
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| series | Acta Biomedica Scientifica |
| spelling | doaj-art-3c5840d9a2964a6bb55f7e008d42f4b32025-07-28T14:03:31ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962024-01-018623424010.29413/ABS.2023-8.6.232674The effect of complex pharmacotherapy regimens using a herbal remedy from <i>Hippophae rhamnoides</i> on biochemical blood parameters of rats with paracetamol hepatitisS. Yu. Batueva0G. P. Lamazhapova1Yu. A. Kapustina2O. A. Rodnaeva3S. A. Chukaev4D. Banzarov Buryat State UniversityD. Banzarov Buryat State University; East Siberian State University of Technology and ManagementD. Banzarov Buryat State UniversityD. Banzarov Buryat State UniversityD. Banzarov Buryat State UniversityBackground. The use of complexes of synthetic and herbal remedies as hepatoprotectors in the treatment of liver pathologies of various etiologies is an urgent task of pharmacology. A promising type of medicinal plant raw material is an extract of Hippophaes rhamnoides leaves. The hepatoprotective effect of extract of Hippophaes rhamnoides leaves in combination with ademethionine has not been studied to date.The aim of the research was to study changes in biochemical markers of hepatic function in the application of complex schemes of pharmacotherapy of experimental liver damage with paracetamol using Extractum foliorum Hippophaes rhamnoides.Materials and methods. The experimental study was performed on Wistar rats, the animals were divided into six groups. Group 1 (intact) – animals without a model of liver damage and without treatment; in Group 2 (control) paracetamol was used to create experimental hepatitis without treatment (positive control group); in Group 3 (comparison) a combination of “silibinin + ademethionine” was used on a model of paracetamol hepatitis; in Group 4 (experimental) extract of Hippophaes rhamnoides leaves was used on the model of paracetamol hepatitis; in Group 5 (experimental) ademethionine was used on a model of paracetamol hepatitis; in Group 6 (experimental) a combination of extract of Hippophaes rhamnoides leaves and ademethionine was used on a model of paracetamol hepatitis. The functional state of the liver of experimental animals was determined by biochemical parameters.Results. When using a combination of extract of Hippophaes rhamnoides leaves with ademethionine, the studied biochemical parameters significantly (p < 0.05) differed from the numerical values in the negative control group and were closest to those in the intact group than in other experimental groups.Conclusions. A comparison of the effectiveness of the use of extract of Hippophaes rhamnoides leaves in combination with ademethionine by the total effect on blood biochemical parameters determines this complex as a promising drug for further research.https://www.actabiomedica.ru/jour/article/view/4511extractum foliorum hippophaes rhamnoidesparacetamol experimental hepatitiscomplex pharmacotherapy regimensparacetamolademethionineblood biochemical parameters |
| spellingShingle | S. Yu. Batueva G. P. Lamazhapova Yu. A. Kapustina O. A. Rodnaeva S. A. Chukaev The effect of complex pharmacotherapy regimens using a herbal remedy from <i>Hippophae rhamnoides</i> on biochemical blood parameters of rats with paracetamol hepatitis Acta Biomedica Scientifica extractum foliorum hippophaes rhamnoides paracetamol experimental hepatitis complex pharmacotherapy regimens paracetamol ademethionine blood biochemical parameters |
| title | The effect of complex pharmacotherapy regimens using a herbal remedy from <i>Hippophae rhamnoides</i> on biochemical blood parameters of rats with paracetamol hepatitis |
| title_full | The effect of complex pharmacotherapy regimens using a herbal remedy from <i>Hippophae rhamnoides</i> on biochemical blood parameters of rats with paracetamol hepatitis |
| title_fullStr | The effect of complex pharmacotherapy regimens using a herbal remedy from <i>Hippophae rhamnoides</i> on biochemical blood parameters of rats with paracetamol hepatitis |
| title_full_unstemmed | The effect of complex pharmacotherapy regimens using a herbal remedy from <i>Hippophae rhamnoides</i> on biochemical blood parameters of rats with paracetamol hepatitis |
| title_short | The effect of complex pharmacotherapy regimens using a herbal remedy from <i>Hippophae rhamnoides</i> on biochemical blood parameters of rats with paracetamol hepatitis |
| title_sort | effect of complex pharmacotherapy regimens using a herbal remedy from i hippophae rhamnoides i on biochemical blood parameters of rats with paracetamol hepatitis |
| topic | extractum foliorum hippophaes rhamnoides paracetamol experimental hepatitis complex pharmacotherapy regimens paracetamol ademethionine blood biochemical parameters |
| url | https://www.actabiomedica.ru/jour/article/view/4511 |
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