An efficient intramolecular domino cyclization/Friedel–Crafts type transformation of N-(alkenyl)-amide-1,6-enynes has been developed under silver, gold, and platinum catalysis. The optimization of this process in the presence of silver complexes led to functionalized tri- and tetracyclic derivatives...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Académie des sciences
2025-02-01
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| Series: | Comptes Rendus. Chimie |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.357/ |
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| Summary: | An efficient intramolecular domino cyclization/Friedel–Crafts type transformation of N-(alkenyl)-amide-1,6-enynes has been developed under silver, gold, and platinum catalysis. The optimization of this process in the presence of silver complexes led to functionalized tri- and tetracyclic derivatives in good to excellent yields. The reaction conditions were found to be amenable with electron-donating and electron-withdrawing groups (12 polycyclic adducts). For mono- and non-substituted enynes, gold and platinum complexes were found to be efficient. |
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| ISSN: | 1878-1543 |