HBP21 Alleviates Sepsis-Induced Acute Kidney Injury by Targeting PI3K/AKT-Mediated M1 Macrophage Polarization
Conclusion: These findings suggest that HBP21 mitigates S-AKI pathogenesis via PI3K/AKT-mediated M2 macrophage polarization, underscoring its translational potential in renal injury therapy.
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/mi/9021628 |
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| _version_ | 1839582964526088192 |
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| author | Na An Mingzhi Xu Ruman Chen Cuijuan Wang Yafei Bai |
| author_facet | Na An Mingzhi Xu Ruman Chen Cuijuan Wang Yafei Bai |
| author_sort | Na An |
| collection | DOAJ |
| description | Conclusion: These findings suggest that HBP21 mitigates S-AKI pathogenesis via PI3K/AKT-mediated M2 macrophage polarization, underscoring its translational potential in renal injury therapy. |
| format | Article |
| id | doaj-art-3bb1a5a8c1f34c53b366ebbab90c65d9 |
| institution | Matheson Library |
| issn | 1466-1861 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3bb1a5a8c1f34c53b366ebbab90c65d92025-08-04T00:00:03ZengWileyMediators of Inflammation1466-18612025-01-01202510.1155/mi/9021628HBP21 Alleviates Sepsis-Induced Acute Kidney Injury by Targeting PI3K/AKT-Mediated M1 Macrophage PolarizationNa An0Mingzhi Xu1Ruman Chen2Cuijuan Wang3Yafei Bai4Blood Purification Center of Hainan General HospitalBlood Purification Center of Hainan General HospitalBlood Purification Center of Hainan General HospitalBlood Purification Center of Hainan General HospitalBlood Purification Center of Hainan General HospitalConclusion: These findings suggest that HBP21 mitigates S-AKI pathogenesis via PI3K/AKT-mediated M2 macrophage polarization, underscoring its translational potential in renal injury therapy.http://dx.doi.org/10.1155/mi/9021628 |
| spellingShingle | Na An Mingzhi Xu Ruman Chen Cuijuan Wang Yafei Bai HBP21 Alleviates Sepsis-Induced Acute Kidney Injury by Targeting PI3K/AKT-Mediated M1 Macrophage Polarization Mediators of Inflammation |
| title | HBP21 Alleviates Sepsis-Induced Acute Kidney Injury by Targeting PI3K/AKT-Mediated M1 Macrophage Polarization |
| title_full | HBP21 Alleviates Sepsis-Induced Acute Kidney Injury by Targeting PI3K/AKT-Mediated M1 Macrophage Polarization |
| title_fullStr | HBP21 Alleviates Sepsis-Induced Acute Kidney Injury by Targeting PI3K/AKT-Mediated M1 Macrophage Polarization |
| title_full_unstemmed | HBP21 Alleviates Sepsis-Induced Acute Kidney Injury by Targeting PI3K/AKT-Mediated M1 Macrophage Polarization |
| title_short | HBP21 Alleviates Sepsis-Induced Acute Kidney Injury by Targeting PI3K/AKT-Mediated M1 Macrophage Polarization |
| title_sort | hbp21 alleviates sepsis induced acute kidney injury by targeting pi3k akt mediated m1 macrophage polarization |
| url | http://dx.doi.org/10.1155/mi/9021628 |
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