Assessing the Activity of Renin and GST in the Serum of Ladies Suffering from Polycystic Ovary Syndrome and COVID-19 to Predict the Danger of Cardiac Disease
The coronavirus-pandemic has a major impact on women's-mental and physical-health. Polycystic-ovary-syndrome (PCOS) has a high-predisposition to many cardiometabolic-risk factors that increase susceptibility to severe complications of COVID-19 and also exhibit an increased likelihood of subfer...
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University of Baghdad, College of Science for Women
2023-06-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7879 |
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| author | Shaimaa Emad Ali Fayhaa M. Khaleel |
| author_facet | Shaimaa Emad Ali Fayhaa M. Khaleel |
| author_sort | Shaimaa Emad Ali |
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The coronavirus-pandemic has a major impact on women's-mental and physical-health. Polycystic-ovary-syndrome (PCOS) has a high-predisposition to many cardiometabolic-risk factors that increase susceptibility to severe complications of COVID-19 and also exhibit an increased likelihood of subfertility. The study includes the extent of the effect of COVID-19-virus on renin-levels, glutathione-s-transferase-activity and other biochemical parameters in PCOS-women. The study included 120 samples of ladies that involved: 80 PCOS-patients, and 40 healthy-ladies. Both main groups were divided into subgroups based on COVID-19 infected or not. Blood-samples were collected from PCOS-patients in Kamal-Al-Samara Hospital, at the period between December until June. Some biochemical parameters were measured for all study-groups, which included: determination of serum renin levels by using the ELISA-technique, GST-activity, lipid-profile. FBS was assessed manually, and hormones were assessed using VIDAS-analyzer-hormones. The result showed a possible relationship between FBS-levels and renin in PCOS-ladies (Stein-Leventhal-Syndrome), while GST-activity were inversely associated with BMI in PCOS-ladies. Also, it was found that the renin-levels were higher in PCOS-patients groups compared with healthy-groups. On the other hand, the renin levels and Glutathione-S-Transferase-activity were lower in PCOS-patients-infected-with-COVID-19 than female-patients-without-COVID-19. The statistical-data-displayed that the level of renin is associated negatively with glutathione-s-transferase-activity in PCOS-cases. Renin level was higher in PCOS-ladies, this may lead to increase renal-dysfunction and risk of cardiovascular-disease that may be expected in patients. A decrease in the antioxidant-capacity may be because the high number of free-radicals that enter the body by the virus and high levels of renin which lead to a higher risk of PCOS-complication like cardiovascular-disease.
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| format | Article |
| id | doaj-art-3a330abd6d8a4093b6a4e5f86b27eb2f |
| institution | Matheson Library |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | University of Baghdad, College of Science for Women |
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| series | مجلة بغداد للعلوم |
| spelling | doaj-art-3a330abd6d8a4093b6a4e5f86b27eb2f2025-08-02T05:35:20ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862023-06-01203(Suppl.)10.21123/bsj.2023.7879Assessing the Activity of Renin and GST in the Serum of Ladies Suffering from Polycystic Ovary Syndrome and COVID-19 to Predict the Danger of Cardiac DiseaseShaimaa Emad Ali0Fayhaa M. Khaleel1Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq.Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq. The coronavirus-pandemic has a major impact on women's-mental and physical-health. Polycystic-ovary-syndrome (PCOS) has a high-predisposition to many cardiometabolic-risk factors that increase susceptibility to severe complications of COVID-19 and also exhibit an increased likelihood of subfertility. The study includes the extent of the effect of COVID-19-virus on renin-levels, glutathione-s-transferase-activity and other biochemical parameters in PCOS-women. The study included 120 samples of ladies that involved: 80 PCOS-patients, and 40 healthy-ladies. Both main groups were divided into subgroups based on COVID-19 infected or not. Blood-samples were collected from PCOS-patients in Kamal-Al-Samara Hospital, at the period between December until June. Some biochemical parameters were measured for all study-groups, which included: determination of serum renin levels by using the ELISA-technique, GST-activity, lipid-profile. FBS was assessed manually, and hormones were assessed using VIDAS-analyzer-hormones. The result showed a possible relationship between FBS-levels and renin in PCOS-ladies (Stein-Leventhal-Syndrome), while GST-activity were inversely associated with BMI in PCOS-ladies. Also, it was found that the renin-levels were higher in PCOS-patients groups compared with healthy-groups. On the other hand, the renin levels and Glutathione-S-Transferase-activity were lower in PCOS-patients-infected-with-COVID-19 than female-patients-without-COVID-19. The statistical-data-displayed that the level of renin is associated negatively with glutathione-s-transferase-activity in PCOS-cases. Renin level was higher in PCOS-ladies, this may lead to increase renal-dysfunction and risk of cardiovascular-disease that may be expected in patients. A decrease in the antioxidant-capacity may be because the high number of free-radicals that enter the body by the virus and high levels of renin which lead to a higher risk of PCOS-complication like cardiovascular-disease. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7879Angiotensin-converting enzyme 2, Body mass index, COVID-19, Glutathione-S-Transferase, Polycystic ovary syndrome |
| spellingShingle | Shaimaa Emad Ali Fayhaa M. Khaleel Assessing the Activity of Renin and GST in the Serum of Ladies Suffering from Polycystic Ovary Syndrome and COVID-19 to Predict the Danger of Cardiac Disease مجلة بغداد للعلوم Angiotensin-converting enzyme 2, Body mass index, COVID-19, Glutathione-S-Transferase, Polycystic ovary syndrome |
| title | Assessing the Activity of Renin and GST in the Serum of Ladies Suffering from Polycystic Ovary Syndrome and COVID-19 to Predict the Danger of Cardiac Disease |
| title_full | Assessing the Activity of Renin and GST in the Serum of Ladies Suffering from Polycystic Ovary Syndrome and COVID-19 to Predict the Danger of Cardiac Disease |
| title_fullStr | Assessing the Activity of Renin and GST in the Serum of Ladies Suffering from Polycystic Ovary Syndrome and COVID-19 to Predict the Danger of Cardiac Disease |
| title_full_unstemmed | Assessing the Activity of Renin and GST in the Serum of Ladies Suffering from Polycystic Ovary Syndrome and COVID-19 to Predict the Danger of Cardiac Disease |
| title_short | Assessing the Activity of Renin and GST in the Serum of Ladies Suffering from Polycystic Ovary Syndrome and COVID-19 to Predict the Danger of Cardiac Disease |
| title_sort | assessing the activity of renin and gst in the serum of ladies suffering from polycystic ovary syndrome and covid 19 to predict the danger of cardiac disease |
| topic | Angiotensin-converting enzyme 2, Body mass index, COVID-19, Glutathione-S-Transferase, Polycystic ovary syndrome |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7879 |
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