Experimental Estimation of Immunomodulating Activity of Tubosan, a New Russian Synthetic Drug
Tubosan, a new Russian immunostimulator is a derivative of sulfopyrimidine. It stimulated the humoral antiviral immunity in mice, provoked increasing the number of the antibody forming cells in the spleen of mice, immunized by sheep's erythrocytes, and increased the titers of the virus-neutrali...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/564 |
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| _version_ | 1839591168747241472 |
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| author | N. K. Chernikova V. V. Mikhailov S. V. Borisevich |
| author_facet | N. K. Chernikova V. V. Mikhailov S. V. Borisevich |
| author_sort | N. K. Chernikova |
| collection | DOAJ |
| description | Tubosan, a new Russian immunostimulator is a derivative of sulfopyrimidine. It stimulated the humoral antiviral immunity in mice, provoked increasing the number of the antibody forming cells in the spleen of mice, immunized by sheep's erythrocytes, and increased the titers of the virus-neutralizing antibodies after immunization by inactivated and live vaccines VEE. The Tubosan ability to lower the reactogenicity of the live VEE vaccine provided new perspectives for using such immunomodulators in medical practice. |
| format | Article |
| id | doaj-art-39c132ffb7d14a3f9de86d3d43e0d87c |
| institution | Matheson Library |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-39c132ffb7d14a3f9de86d3d43e0d87c2025-08-03T13:04:47ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01599-101316563Experimental Estimation of Immunomodulating Activity of Tubosan, a New Russian Synthetic DrugN. K. Chernikova0V. V. Mikhailov1S. V. Borisevich2Central Research Institute No. 48, Ministry of Defense of the Russian FederationSergiev Posad Biopharm Pravo-AlphaCentral Research Institute No. 48, Ministry of Defense of the Russian FederationTubosan, a new Russian immunostimulator is a derivative of sulfopyrimidine. It stimulated the humoral antiviral immunity in mice, provoked increasing the number of the antibody forming cells in the spleen of mice, immunized by sheep's erythrocytes, and increased the titers of the virus-neutralizing antibodies after immunization by inactivated and live vaccines VEE. The Tubosan ability to lower the reactogenicity of the live VEE vaccine provided new perspectives for using such immunomodulators in medical practice.https://www.antibiotics-chemotherapy.ru/jour/article/view/564immunostimulatorimmune responsereactogenicity |
| spellingShingle | N. K. Chernikova V. V. Mikhailov S. V. Borisevich Experimental Estimation of Immunomodulating Activity of Tubosan, a New Russian Synthetic Drug Антибиотики и Химиотерапия immunostimulator immune response reactogenicity |
| title | Experimental Estimation of Immunomodulating Activity of Tubosan, a New Russian Synthetic Drug |
| title_full | Experimental Estimation of Immunomodulating Activity of Tubosan, a New Russian Synthetic Drug |
| title_fullStr | Experimental Estimation of Immunomodulating Activity of Tubosan, a New Russian Synthetic Drug |
| title_full_unstemmed | Experimental Estimation of Immunomodulating Activity of Tubosan, a New Russian Synthetic Drug |
| title_short | Experimental Estimation of Immunomodulating Activity of Tubosan, a New Russian Synthetic Drug |
| title_sort | experimental estimation of immunomodulating activity of tubosan a new russian synthetic drug |
| topic | immunostimulator immune response reactogenicity |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/564 |
| work_keys_str_mv | AT nkchernikova experimentalestimationofimmunomodulatingactivityoftubosananewrussiansyntheticdrug AT vvmikhailov experimentalestimationofimmunomodulatingactivityoftubosananewrussiansyntheticdrug AT svborisevich experimentalestimationofimmunomodulatingactivityoftubosananewrussiansyntheticdrug |