Prenatal stress increases corticosterone levels in offspring by impairing placental glucocorticoid barrier function.

This study aimed to investigate the association between prenatal stress (PS) and corticosterone levels, and its influence on DNA methylation of genes related to the placental glucocorticoid (GC) barrier, including 11β-HSD2, ABCB1 (P-gp), NR3C1, and FKBP5. The PS model was established through chronic...

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Bibliographic Details
Main Authors: Can Liu, Hongya Liu, Hongyu Li, Deguang Yang, Ye Li, Rui Wang, Jiashu Zhu, Shuqin Ma, Suzhen Guan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0313705
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