Biological testing of titanium-containing implants with noble metal coatings in an <I>in vivo</I> experiment
The aim of study is to conduct in vivo biological testing of titanium nickelide samples modifed with Ag/Pt or AuAg/Pt flm heterostructures in comparison with the bare carrier.Material and Methods. Titanium nickelide plates modifed with flm heterostructures made of noble metals and the laboratory min...
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| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2024-11-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/3270 |
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| author | A. A. Zheravin S. I. Dorovskikh E. S. Vikulova T. V. Basova M. B. Vasileva Ya. L. Rusakova N. B. Morozova |
| author_facet | A. A. Zheravin S. I. Dorovskikh E. S. Vikulova T. V. Basova M. B. Vasileva Ya. L. Rusakova N. B. Morozova |
| author_sort | A. A. Zheravin |
| collection | DOAJ |
| description | The aim of study is to conduct in vivo biological testing of titanium nickelide samples modifed with Ag/Pt or AuAg/Pt flm heterostructures in comparison with the bare carrier.Material and Methods. Titanium nickelide plates modifed with flm heterostructures made of noble metals and the laboratory mini-pigs used for in vivo tests were the objects of the study. To form flm structures on titanium nickelide samples, the physical gasphase deposition methods: ion plasma deposition (IPD) and thermal (PVD) sputtering were used. The Ag/ Pt or AuAg/Pt heterostructures were characterized by X-ray diffraction and scanning microscopy methods.Results. The biocompatibility of implants before (TiNi, control) and after (Ag/Pt/TiNi and AuAg/Pt/TiNi) modifcation with flm heterostructures was tested in in-vivo experiments on a laboratory animal (mini-pig). General toxic reactions of the body to the injected samples were absent. A comparative macroscopic and histological analysis of the condition of peri-implant tissues after 39 days of implantation was performed. The connective tissue capsule around the TiNi sample revealed the presence of a certain number of lymphocytes, eosinophils and macrophages, but these indicators decrease in the order of TiNi > AuAg/Pt/TiNi > Ag/Pt/TiNi.Conclusion. The positive effect of modifying the titanium nickelide surfaces with noble metal heterostructures on the biocompatibility of metal implants was demonstrated in an in vivo experiment. |
| format | Article |
| id | doaj-art-33c0958a10dd4af7aaebf67c6d8dcde7 |
| institution | Matheson Library |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2024-11-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-33c0958a10dd4af7aaebf67c6d8dcde72025-08-04T10:33:44ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682024-11-01235738410.21294/1814-4861-2024-23-5-73-841273Biological testing of titanium-containing implants with noble metal coatings in an <I>in vivo</I> experimentA. A. Zheravin0S. I. Dorovskikh1E. S. Vikulova2T. V. Basova3M. B. Vasileva4Ya. L. Rusakova5N. B. Morozova6A.V. Nikolaev Institute of Inorganic Chemistry SB RAS; E.N. Meshalkin National Medical Research Center of the Ministry of Health of RussiaA.V. Nikolaev Institute of Inorganic Chemistry SB RASA.V. Nikolaev Institute of Inorganic Chemistry SB RASA.V. Nikolaev Institute of Inorganic Chemistry SB RASNovosibirsk National Research State UniversityE.N. Meshalkin National Medical Research Center of the Ministry of Health of RussiaA.V. Nikolaev Institute of Inorganic Chemistry SB RASThe aim of study is to conduct in vivo biological testing of titanium nickelide samples modifed with Ag/Pt or AuAg/Pt flm heterostructures in comparison with the bare carrier.Material and Methods. Titanium nickelide plates modifed with flm heterostructures made of noble metals and the laboratory mini-pigs used for in vivo tests were the objects of the study. To form flm structures on titanium nickelide samples, the physical gasphase deposition methods: ion plasma deposition (IPD) and thermal (PVD) sputtering were used. The Ag/ Pt or AuAg/Pt heterostructures were characterized by X-ray diffraction and scanning microscopy methods.Results. The biocompatibility of implants before (TiNi, control) and after (Ag/Pt/TiNi and AuAg/Pt/TiNi) modifcation with flm heterostructures was tested in in-vivo experiments on a laboratory animal (mini-pig). General toxic reactions of the body to the injected samples were absent. A comparative macroscopic and histological analysis of the condition of peri-implant tissues after 39 days of implantation was performed. The connective tissue capsule around the TiNi sample revealed the presence of a certain number of lymphocytes, eosinophils and macrophages, but these indicators decrease in the order of TiNi > AuAg/Pt/TiNi > Ag/Pt/TiNi.Conclusion. The positive effect of modifying the titanium nickelide surfaces with noble metal heterostructures on the biocompatibility of metal implants was demonstrated in an in vivo experiment.https://www.siboncoj.ru/jour/article/view/3270implantantibacterial agentcoatingplatinumsilvergoldimplantationx-ray studyhistological study |
| spellingShingle | A. A. Zheravin S. I. Dorovskikh E. S. Vikulova T. V. Basova M. B. Vasileva Ya. L. Rusakova N. B. Morozova Biological testing of titanium-containing implants with noble metal coatings in an <I>in vivo</I> experiment Сибирский онкологический журнал implant antibacterial agent coating platinum silver gold implantation x-ray study histological study |
| title | Biological testing of titanium-containing implants with noble metal coatings in an <I>in vivo</I> experiment |
| title_full | Biological testing of titanium-containing implants with noble metal coatings in an <I>in vivo</I> experiment |
| title_fullStr | Biological testing of titanium-containing implants with noble metal coatings in an <I>in vivo</I> experiment |
| title_full_unstemmed | Biological testing of titanium-containing implants with noble metal coatings in an <I>in vivo</I> experiment |
| title_short | Biological testing of titanium-containing implants with noble metal coatings in an <I>in vivo</I> experiment |
| title_sort | biological testing of titanium containing implants with noble metal coatings in an i in vivo i experiment |
| topic | implant antibacterial agent coating platinum silver gold implantation x-ray study histological study |
| url | https://www.siboncoj.ru/jour/article/view/3270 |
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