Hederagenin promotes SIRT6 to attenuate epidural scar formation by aggravating PRMT1 deacetylation

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Hederagenin promotes SIRT6 to attenuate epidural scar formation by aggravating PRMT1 deacetylation

Aims: The formation of a postoperative epidural scar induced by epidural fibrosis is the main reason for recurrence of lumbar disc herniation after laminectomy. Hederagenin (HE) has been found to be widely present in various medicinal plants and has various pharmacological functions. This study aim...

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Bibliographic Details
Main Authors:	Xiao-Chen Fan, Jue Wang
Format:	Article
Language:	English
Published:	The British Editorial Society of Bone & Joint Surgery 2025-06-01
Series:	Bone & Joint Research
Subjects:	hederagenin deacetylation endoplasmic reticulum stress epidural scar formation sirt6 fibrosis fibroblasts transforming growth factor beta 1 apoptosis western blotting laminectomy nuclear factor-κb arginine flow cytometry lumbar disc herniation
Online Access:	https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.146.BJR-2024-0287.R2
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