Disruption of cell-intrinsic PCSK9 enhances the antitumor efficacy of CD8+ T cells
Background Tumor-derived proprotein convertase subtilisin/kexin type 9 (PCSK9) facilitates tumor progression, but the role of immune cell-intrinsic PCSK9 in tumor control remains unclear.Methods Orthotopic models of pancreatic cancer and melanoma in Pcsk9-deficient mice were established and tumor-in...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2025-07-01
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| Series: | Journal for ImmunoTherapy of Cancer |
| Online Access: | https://jitc.bmj.com/content/13/7/e011657.full |
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