Evolutionary dynamics of recurrent hepatocellular carcinoma under divergent immune selection pressures

Hepatocellular carcinoma (HCC) is a highly lethal, aggressive malignancy. Little is known about the evolutionary trajectories of HCC and how clinical decision-making could be informed based on biopsies of the initial tumour. Here, we report the whole-exome sequencing of a unique series of resected H...

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Autores principales:	Ankur Chakravarthy, Elisa Pasini, Xun Zhao, Jeffrey To, Shu Yi (Roxana) Shen, Sandra Fischer, Anand Ghanekar, Arndt Vogel, Robert C. Grant, Jennifer Knox, Gonzalo Sapisochin, Gregory J. Gores, Daniel De Carvalho, Mamatha Bhat
Formato:	Artículo
Lenguaje:	inglés
Publicado:	Frontiers Media S.A. 2025-08-01
Colección:	Frontiers in Oncology
Materias:	hepatocellular carcinoma tumour evolution immune selection immune evasion whole-exome sequencing
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1537087/full
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Evolutionary dynamics of recurrent hepatocellular carcinoma under divergent immune selection pressures

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