Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer

Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer

IntroductionThe ketogenic diet (KD) increases mouse lifespan and health span, and improves late-life memory. This raises the question regarding the mechanism behind this effect. In mice on a KD, blood beta-hydroxybutyrate (BHB) levels uniquely rise higher than those of mice on a control diet (CD). B...

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Bibliographic Details
Main Authors: Chase Garcia, Ariana Banerjee, Claire Montgomery, Lauren Adcock, Izumi Maezawa, Jon Ramsey, Ana Cristina G. Grodzki, Kyoungmi Kim, Gino Cortopassi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Aging
Subjects:
Alzheimer’s
microglia
ketone
beta-hydroxybutyrate
TREM2
BHB
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2025.1628835/full
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https://www.frontiersin.org/articles/10.3389/fragi.2025.1628835/full

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