Age-Specific Clinical and Laboratory Features and Renal Involvement in Children with MIS-C: A Single Tertiary Centre Experience from Vojvodina
<i>Backgrounds and Objectives</i>: Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but potentially severe complication of SARS-CoV-2 infection, with increasingly reported renal manifestations. <i>Materials and Methods</i>: The aim of this retrospective study w...
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2025-06-01
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| author | Borko Milanović Vesna Stojanović Gordana Vijatov-Ðurić Marijana Savin Andrea Ðuretić Jelena Kesić Nenad Barišić Ognjen Ležakov Ivana Vorgučin Gordana Vilotijević-Dautović Katarina Koprivšek |
| author_facet | Borko Milanović Vesna Stojanović Gordana Vijatov-Ðurić Marijana Savin Andrea Ðuretić Jelena Kesić Nenad Barišić Ognjen Ležakov Ivana Vorgučin Gordana Vilotijević-Dautović Katarina Koprivšek |
| author_sort | Borko Milanović |
| collection | DOAJ |
| description | <i>Backgrounds and Objectives</i>: Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but potentially severe complication of SARS-CoV-2 infection, with increasingly reported renal manifestations. <i>Materials and Methods</i>: The aim of this retrospective study was to compare clinical and laboratory characteristics across age categories, with special emphasis on renal function. We analysed data from 64 patients with MIS-C treated between July 2020 and December 2023. <i>Results</i>: In children under 3 years of age, there was a higher prevalence of leucocytosis, elevated platelet counts, and anaemia, along with a lower frequency of complications. The 3–6-year age group was characterized by the presence of rash, hypoalbuminemia, and elevated transaminases. The 7–12-year age group showed the highest rate of organ dysfunction. In adolescents (13–18 years), neurological symptoms, the highest BMI values, the greatest prevalence of comorbidities, leukopenia, lymphopenia, and elevated GGT levels were observed. The incidence of acute kidney injury (AKI) was 6.3% (<i>n</i> = 4/64). Following treatment, the majority of patients achieved full recovery (<i>n</i> = 61/64; 95.2%). <i>Conclusions</i>: There are pronounced age-related differences in the clinical presentation of MIS-C, with distinct immune and clinical patterns suggesting developmental influences on disease expression and outcomes. Older children showed a higher prevalence of comorbidities and organ dysfunction compared to younger patients. Notably, this study found a markedly lower incidence of acute kidney injury (6.3%) compared to previously reported rates (20–30%), indicating potential regional or age-related protective factors. These findings highlight the importance of age-specific evaluation in MIS-C and underscore the need for further multicentre research to refine therapeutic protocols. |
| format | Article |
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| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-06-01 |
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| series | Medicina |
| spelling | doaj-art-31364c37d79f4012bc2dc4d4a47b9c6f2025-07-25T13:29:15ZengMDPI AGMedicina1010-660X1648-91442025-06-01617114210.3390/medicina61071142Age-Specific Clinical and Laboratory Features and Renal Involvement in Children with MIS-C: A Single Tertiary Centre Experience from VojvodinaBorko Milanović0Vesna Stojanović1Gordana Vijatov-Ðurić2Marijana Savin3Andrea Ðuretić4Jelena Kesić5Nenad Barišić6Ognjen Ležakov7Ivana Vorgučin8Gordana Vilotijević-Dautović9Katarina Koprivšek10Medical Faculty of Novi Sad, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaMedical Faculty of Novi Sad, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaMedical Faculty of Novi Sad, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaMedical Faculty of Novi Sad, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaInstitute for Child and Youth Healthcare of Vojvodina, Hajduk Veljkova 10, 21000 Novi Sad, SerbiaMedical Faculty of Novi Sad, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaMedical Faculty of Novi Sad, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaMedical Faculty of Novi Sad, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaMedical Faculty of Novi Sad, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaMedical Faculty of Novi Sad, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, SerbiaMedical Faculty of Novi Sad, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia<i>Backgrounds and Objectives</i>: Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but potentially severe complication of SARS-CoV-2 infection, with increasingly reported renal manifestations. <i>Materials and Methods</i>: The aim of this retrospective study was to compare clinical and laboratory characteristics across age categories, with special emphasis on renal function. We analysed data from 64 patients with MIS-C treated between July 2020 and December 2023. <i>Results</i>: In children under 3 years of age, there was a higher prevalence of leucocytosis, elevated platelet counts, and anaemia, along with a lower frequency of complications. The 3–6-year age group was characterized by the presence of rash, hypoalbuminemia, and elevated transaminases. The 7–12-year age group showed the highest rate of organ dysfunction. In adolescents (13–18 years), neurological symptoms, the highest BMI values, the greatest prevalence of comorbidities, leukopenia, lymphopenia, and elevated GGT levels were observed. The incidence of acute kidney injury (AKI) was 6.3% (<i>n</i> = 4/64). Following treatment, the majority of patients achieved full recovery (<i>n</i> = 61/64; 95.2%). <i>Conclusions</i>: There are pronounced age-related differences in the clinical presentation of MIS-C, with distinct immune and clinical patterns suggesting developmental influences on disease expression and outcomes. Older children showed a higher prevalence of comorbidities and organ dysfunction compared to younger patients. Notably, this study found a markedly lower incidence of acute kidney injury (6.3%) compared to previously reported rates (20–30%), indicating potential regional or age-related protective factors. These findings highlight the importance of age-specific evaluation in MIS-C and underscore the need for further multicentre research to refine therapeutic protocols.https://www.mdpi.com/1648-9144/61/7/1142COVID-19MIS-Cmultisystem inflammatory syndromeSARS-CoV-2childkidney diseases |
| spellingShingle | Borko Milanović Vesna Stojanović Gordana Vijatov-Ðurić Marijana Savin Andrea Ðuretić Jelena Kesić Nenad Barišić Ognjen Ležakov Ivana Vorgučin Gordana Vilotijević-Dautović Katarina Koprivšek Age-Specific Clinical and Laboratory Features and Renal Involvement in Children with MIS-C: A Single Tertiary Centre Experience from Vojvodina Medicina COVID-19 MIS-C multisystem inflammatory syndrome SARS-CoV-2 child kidney diseases |
| title | Age-Specific Clinical and Laboratory Features and Renal Involvement in Children with MIS-C: A Single Tertiary Centre Experience from Vojvodina |
| title_full | Age-Specific Clinical and Laboratory Features and Renal Involvement in Children with MIS-C: A Single Tertiary Centre Experience from Vojvodina |
| title_fullStr | Age-Specific Clinical and Laboratory Features and Renal Involvement in Children with MIS-C: A Single Tertiary Centre Experience from Vojvodina |
| title_full_unstemmed | Age-Specific Clinical and Laboratory Features and Renal Involvement in Children with MIS-C: A Single Tertiary Centre Experience from Vojvodina |
| title_short | Age-Specific Clinical and Laboratory Features and Renal Involvement in Children with MIS-C: A Single Tertiary Centre Experience from Vojvodina |
| title_sort | age specific clinical and laboratory features and renal involvement in children with mis c a single tertiary centre experience from vojvodina |
| topic | COVID-19 MIS-C multisystem inflammatory syndrome SARS-CoV-2 child kidney diseases |
| url | https://www.mdpi.com/1648-9144/61/7/1142 |
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