The role of dutasteride in reducing complications of transurethral resection of prostate
Purpose: To evaluate the superiority of dutasteride over a placebo in patients having their prostate removed during transurethral resection for benign prostate hyperplasia. Material and Methods: The study included a total of 30 patients, with 15 patients allocated to each group (group placebo and gr...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Al Ameen Medical College
2025-07-01
|
| Series: | Al Ameen Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://ajms.alameenmedical.org/ArticlePDFs/10%20AJMS%20V18.N3.2025%20p%20215-220.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839635991726391296 |
|---|---|
| author | Shyamal Shah P. Periasamy |
| author_facet | Shyamal Shah P. Periasamy |
| author_sort | Shyamal Shah |
| collection | DOAJ |
| description | Purpose: To evaluate the superiority of dutasteride over a placebo in patients having their prostate removed during transurethral resection for benign prostate hyperplasia. Material and Methods: The study included a total of 30 patients, with 15 patients allocated to each group (group placebo and group B- Dutasteride). Group A received a placebo for two weeks before surgery and two weeks after surgery and group B received dutasteride respective time slots. Result: TURP tissue weight among the placebo and Dutasteride groups, the mean resected tissue weights were 25.86 and 29.6 grams, respectively. The study also examined micro vessel density (MVD) in the suburethral portion of prostatic tissue, which was found to be highest in the placebo group (22.05) compared to the Dutasteride (16.2) group. In the hyperplastic portion of prostatic tissue, MVD was slightly higher in the placebo group (16.04) than in the Dutasteride (14.86) group. Conclusions: Preoperative treatment with dutasteride for two weeks before TURP reduces surgical bleeding and length of hospitalization after TURP. This pre-treatment can be used to decrease surgical bleeding associated with the TURP. |
| format | Article |
| id | doaj-art-30c38b0b0dd146fea8c52b35cda60c9b |
| institution | Matheson Library |
| issn | 0974-1143 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Al Ameen Medical College |
| record_format | Article |
| series | Al Ameen Journal of Medical Sciences |
| spelling | doaj-art-30c38b0b0dd146fea8c52b35cda60c9b2025-07-08T11:14:16ZengAl Ameen Medical CollegeAl Ameen Journal of Medical Sciences0974-11432025-07-011803215220The role of dutasteride in reducing complications of transurethral resection of prostateShyamal Shah0P. Periasamy1Department of Urology, Chettinad Super Speciality Hospital, Rajiv Gandhi Salai OMR, Kelambakkam, Chennai-603103, Tamil Nadu, IndiaDepartment of Urology, Chettinad Super Speciality Hospital, Rajiv Gandhi Salai OMR, Kelambakkam, Chennai-603103, Tamil Nadu, IndiaPurpose: To evaluate the superiority of dutasteride over a placebo in patients having their prostate removed during transurethral resection for benign prostate hyperplasia. Material and Methods: The study included a total of 30 patients, with 15 patients allocated to each group (group placebo and group B- Dutasteride). Group A received a placebo for two weeks before surgery and two weeks after surgery and group B received dutasteride respective time slots. Result: TURP tissue weight among the placebo and Dutasteride groups, the mean resected tissue weights were 25.86 and 29.6 grams, respectively. The study also examined micro vessel density (MVD) in the suburethral portion of prostatic tissue, which was found to be highest in the placebo group (22.05) compared to the Dutasteride (16.2) group. In the hyperplastic portion of prostatic tissue, MVD was slightly higher in the placebo group (16.04) than in the Dutasteride (14.86) group. Conclusions: Preoperative treatment with dutasteride for two weeks before TURP reduces surgical bleeding and length of hospitalization after TURP. This pre-treatment can be used to decrease surgical bleeding associated with the TURP.https://ajms.alameenmedical.org/ArticlePDFs/10%20AJMS%20V18.N3.2025%20p%20215-220.pdfdutasteridepreoperative dosemicrovascular densityturp |
| spellingShingle | Shyamal Shah P. Periasamy The role of dutasteride in reducing complications of transurethral resection of prostate Al Ameen Journal of Medical Sciences dutasteride preoperative dose microvascular density turp |
| title | The role of dutasteride in reducing complications of transurethral resection of prostate |
| title_full | The role of dutasteride in reducing complications of transurethral resection of prostate |
| title_fullStr | The role of dutasteride in reducing complications of transurethral resection of prostate |
| title_full_unstemmed | The role of dutasteride in reducing complications of transurethral resection of prostate |
| title_short | The role of dutasteride in reducing complications of transurethral resection of prostate |
| title_sort | role of dutasteride in reducing complications of transurethral resection of prostate |
| topic | dutasteride preoperative dose microvascular density turp |
| url | https://ajms.alameenmedical.org/ArticlePDFs/10%20AJMS%20V18.N3.2025%20p%20215-220.pdf |
| work_keys_str_mv | AT shyamalshah theroleofdutasterideinreducingcomplicationsoftransurethralresectionofprostate AT pperiasamy theroleofdutasterideinreducingcomplicationsoftransurethralresectionofprostate AT shyamalshah roleofdutasterideinreducingcomplicationsoftransurethralresectionofprostate AT pperiasamy roleofdutasterideinreducingcomplicationsoftransurethralresectionofprostate |