Influence of Technological Process Parameters on Microcapsulation of Substances with Unsatisfactory Technological Properties
Introduction. The article presents the results of a study of the influence of parameters of microcapsulation on the properties of microcapsules obtained by diffusion of an emulsion solvent. The results obtained made it possible to establish optimal parameters of the process, such as the mixing speed...
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| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2023-12-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/1649 |
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| author | I. D. Kasymov A. L. Marchenko A. V. Basevich M. E. Valeeva |
| author_facet | I. D. Kasymov A. L. Marchenko A. V. Basevich M. E. Valeeva |
| author_sort | I. D. Kasymov |
| collection | DOAJ |
| description | Introduction. The article presents the results of a study of the influence of parameters of microcapsulation on the properties of microcapsules obtained by diffusion of an emulsion solvent. The results obtained made it possible to establish optimal parameters of the process, such as the mixing speed, the type of mixing device, the volume of the aqueous phase, the concentration of the polymer in the oil phase, the ratio of medicinal substance : polymer, temperature conditions.Aim. The aim of the work was to study the influence of the parameters of the microcapsulation process on the properties of microcapsules obtained by diffusion of an emulsion solvent.Materials and methods. Ibuprofen was used as a model substance for microcapsulation. Eudragit® RS 100 was chosen as the carrier polymer. To assess the shape and nature of the microcapsule surface, a microscope Levenhuk D80L LCD was used, and the size of microcapsules was determined using a laser particle analyzer Microsizer 201C (VA Instalt, Russia).Results and discussion. The influence of the parameters of the microcapsulation process on the properties of ibuprofen microcapsules as a model substance obtained by diffusion of an emulsion solvent has been studied. The optimal parameters of the technology are established, the dependences between the critical parameters of microcapsulation and the properties of the resulting microcapsules are determined.Conclusion. In the course of the study, the choice of technological parameters of microcapsulation by diffusion of an emulsion solvent was proposed and justified. The experimental data obtained on the example of ibuprofen as a model substance will be used as the basis of the experiment when preparing microcapsules based on other substances soluble in organic solvents. |
| format | Article |
| id | doaj-art-306c47a97d9941a09a1a7ab10347e270 |
| institution | Matheson Library |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2023-12-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-306c47a97d9941a09a1a7ab10347e2702025-08-03T19:23:59ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492023-12-0112414615410.33380/2305-2066-2023-12-4-15741163Influence of Technological Process Parameters on Microcapsulation of Substances with Unsatisfactory Technological PropertiesI. D. Kasymov0A. L. Marchenko1A. V. Basevich2M. E. Valeeva3Saint-Petersburg State Chemical and Pharmaceutical UniversitySaint-Petersburg State Chemical and Pharmaceutical UniversitySaint-Petersburg State Chemical and Pharmaceutical UniversitySaint-Petersburg State Chemical and Pharmaceutical UniversityIntroduction. The article presents the results of a study of the influence of parameters of microcapsulation on the properties of microcapsules obtained by diffusion of an emulsion solvent. The results obtained made it possible to establish optimal parameters of the process, such as the mixing speed, the type of mixing device, the volume of the aqueous phase, the concentration of the polymer in the oil phase, the ratio of medicinal substance : polymer, temperature conditions.Aim. The aim of the work was to study the influence of the parameters of the microcapsulation process on the properties of microcapsules obtained by diffusion of an emulsion solvent.Materials and methods. Ibuprofen was used as a model substance for microcapsulation. Eudragit® RS 100 was chosen as the carrier polymer. To assess the shape and nature of the microcapsule surface, a microscope Levenhuk D80L LCD was used, and the size of microcapsules was determined using a laser particle analyzer Microsizer 201C (VA Instalt, Russia).Results and discussion. The influence of the parameters of the microcapsulation process on the properties of ibuprofen microcapsules as a model substance obtained by diffusion of an emulsion solvent has been studied. The optimal parameters of the technology are established, the dependences between the critical parameters of microcapsulation and the properties of the resulting microcapsules are determined.Conclusion. In the course of the study, the choice of technological parameters of microcapsulation by diffusion of an emulsion solvent was proposed and justified. The experimental data obtained on the example of ibuprofen as a model substance will be used as the basis of the experiment when preparing microcapsules based on other substances soluble in organic solvents.https://www.pharmjournal.ru/jour/article/view/1649microcapsulationemulsion solvent diffusion methodibuprofeneudragit |
| spellingShingle | I. D. Kasymov A. L. Marchenko A. V. Basevich M. E. Valeeva Influence of Technological Process Parameters on Microcapsulation of Substances with Unsatisfactory Technological Properties Разработка и регистрация лекарственных средств microcapsulation emulsion solvent diffusion method ibuprofen eudragit |
| title | Influence of Technological Process Parameters on Microcapsulation of Substances with Unsatisfactory Technological Properties |
| title_full | Influence of Technological Process Parameters on Microcapsulation of Substances with Unsatisfactory Technological Properties |
| title_fullStr | Influence of Technological Process Parameters on Microcapsulation of Substances with Unsatisfactory Technological Properties |
| title_full_unstemmed | Influence of Technological Process Parameters on Microcapsulation of Substances with Unsatisfactory Technological Properties |
| title_short | Influence of Technological Process Parameters on Microcapsulation of Substances with Unsatisfactory Technological Properties |
| title_sort | influence of technological process parameters on microcapsulation of substances with unsatisfactory technological properties |
| topic | microcapsulation emulsion solvent diffusion method ibuprofen eudragit |
| url | https://www.pharmjournal.ru/jour/article/view/1649 |
| work_keys_str_mv | AT idkasymov influenceoftechnologicalprocessparametersonmicrocapsulationofsubstanceswithunsatisfactorytechnologicalproperties AT almarchenko influenceoftechnologicalprocessparametersonmicrocapsulationofsubstanceswithunsatisfactorytechnologicalproperties AT avbasevich influenceoftechnologicalprocessparametersonmicrocapsulationofsubstanceswithunsatisfactorytechnologicalproperties AT mevaleeva influenceoftechnologicalprocessparametersonmicrocapsulationofsubstanceswithunsatisfactorytechnologicalproperties |