Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report
Abstract Background It is unclear whether simultaneous primary neoplasm resection and immunotherapy for advanced lung cancer is safe. We report a case of an elderly man with advanced lung cancer and myxofibrosarcoma. Case presentation The advanced lung cancer was treated with pembrolizumab, and part...
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| Format: | Article |
| Language: | English |
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Japan Surgical Society
2019-02-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-019-0596-7 |
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| author | Tetsuya Fukui Yusuke Wakatsuki Tadashi Matsukura |
| author_facet | Tetsuya Fukui Yusuke Wakatsuki Tadashi Matsukura |
| author_sort | Tetsuya Fukui |
| collection | DOAJ |
| description | Abstract Background It is unclear whether simultaneous primary neoplasm resection and immunotherapy for advanced lung cancer is safe. We report a case of an elderly man with advanced lung cancer and myxofibrosarcoma. Case presentation The advanced lung cancer was treated with pembrolizumab, and partial response was achieved in 3 months. However, the mediastinal cyst enlarged rapidly. We resected the mediastinal tumor and diagnosed it as myxofibrosarcoma. The postoperative course was uneventful. Immunotherapy was resumed after the operation without any adverse effects. No recurrence of mediastinal sarcoma or progression of lung cancer was found until the patient died in an accident 8 months after surgery. Conclusion Surgery for mediastinal sarcoma could be performed safely in combination with immunotherapy for advanced lung cancer. |
| format | Article |
| id | doaj-art-302b0cb63f5e4ac7a9feb5a65a15bb8d |
| institution | Matheson Library |
| issn | 2198-7793 |
| language | English |
| publishDate | 2019-02-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-302b0cb63f5e4ac7a9feb5a65a15bb8d2025-07-02T05:28:51ZengJapan Surgical SocietySurgical Case Reports2198-77932019-02-01511310.1186/s40792-019-0596-7Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case reportTetsuya Fukui0Yusuke Wakatsuki1Tadashi Matsukura2Department of General Thoracic Surgery, Japanese Red Cross Fukui HospitalDepartment of General Thoracic Surgery, Japanese Red Cross Fukui HospitalDepartment of General Thoracic Surgery, Japanese Red Cross Fukui HospitalAbstract Background It is unclear whether simultaneous primary neoplasm resection and immunotherapy for advanced lung cancer is safe. We report a case of an elderly man with advanced lung cancer and myxofibrosarcoma. Case presentation The advanced lung cancer was treated with pembrolizumab, and partial response was achieved in 3 months. However, the mediastinal cyst enlarged rapidly. We resected the mediastinal tumor and diagnosed it as myxofibrosarcoma. The postoperative course was uneventful. Immunotherapy was resumed after the operation without any adverse effects. No recurrence of mediastinal sarcoma or progression of lung cancer was found until the patient died in an accident 8 months after surgery. Conclusion Surgery for mediastinal sarcoma could be performed safely in combination with immunotherapy for advanced lung cancer.http://link.springer.com/article/10.1186/s40792-019-0596-7Mediastinal myxofibrosarcomaSurgical resectionLung cancerImmunotherapy |
| spellingShingle | Tetsuya Fukui Yusuke Wakatsuki Tadashi Matsukura Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report Surgical Case Reports Mediastinal myxofibrosarcoma Surgical resection Lung cancer Immunotherapy |
| title | Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report |
| title_full | Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report |
| title_fullStr | Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report |
| title_full_unstemmed | Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report |
| title_short | Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report |
| title_sort | immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma a case report |
| topic | Mediastinal myxofibrosarcoma Surgical resection Lung cancer Immunotherapy |
| url | http://link.springer.com/article/10.1186/s40792-019-0596-7 |
| work_keys_str_mv | AT tetsuyafukui immunotherapyforadvancedlungcancercombinedwithsurgeryformediastinalmyxofibrosarcomaacasereport AT yusukewakatsuki immunotherapyforadvancedlungcancercombinedwithsurgeryformediastinalmyxofibrosarcomaacasereport AT tadashimatsukura immunotherapyforadvancedlungcancercombinedwithsurgeryformediastinalmyxofibrosarcomaacasereport |