Association between braf gene mutation status and clinical-morphological features of cutaneous melanoma
This study identified associations between mutation status of the BRAF gene and the clinico-morphological features of melanoma patients in the South of Russia of the age group over 55 years. It was carried out molecular genetic study of exon 15 of the BRAF gene sequencing method of Sanger and by RT-...
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| Format: | Article |
| Language: | Russian |
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2016-06-01
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| Series: | Кубанский научный медицинский вестник |
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| Online Access: | https://ksma.elpub.ru/jour/article/view/523 |
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| author | O. I. Kit D. I. Vodolazhsky E. Yu. Zlatnik I. Yu. Efimova S. S. Kochuev Yu. V. Przhdetsky |
| author_facet | O. I. Kit D. I. Vodolazhsky E. Yu. Zlatnik I. Yu. Efimova S. S. Kochuev Yu. V. Przhdetsky |
| author_sort | O. I. Kit |
| collection | DOAJ |
| description | This study identified associations between mutation status of the BRAF gene and the clinico-morphological features of melanoma patients in the South of Russia of the age group over 55 years. It was carried out molecular genetic study of exon 15 of the BRAF gene sequencing method of Sanger and by RT-PCR in 35 patients in Southern Russia with morphologically confirmed diagnosis of skin melanoma. The study found that the presence of mutations in the gene BRAF was significantly associated with increasing tumor thickness according to Breslow. We also observed an increase in the frequency of ulceration of the tumor by 21% in patients with an activating V600 mutation. The frequency of detection of V600 mutations in the BRAF gene in tissues of melanoma was 40%. |
| format | Article |
| id | doaj-art-2f6959b60b7d441f9cad0adf2ee28b29 |
| institution | Matheson Library |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| publishDate | 2016-06-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj-art-2f6959b60b7d441f9cad0adf2ee28b292025-08-04T13:05:09ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442016-06-0136771523Association between braf gene mutation status and clinical-morphological features of cutaneous melanomaO. I. Kit0D. I. Vodolazhsky1E. Yu. Zlatnik2I. Yu. Efimova3S. S. Kochuev4Yu. V. Przhdetsky5Rostov research institute of oncologyRostov research institute of oncologyRostov research institute of oncologyRostov research institute of oncologyRostov research institute of oncologyRostov research institute of oncologyThis study identified associations between mutation status of the BRAF gene and the clinico-morphological features of melanoma patients in the South of Russia of the age group over 55 years. It was carried out molecular genetic study of exon 15 of the BRAF gene sequencing method of Sanger and by RT-PCR in 35 patients in Southern Russia with morphologically confirmed diagnosis of skin melanoma. The study found that the presence of mutations in the gene BRAF was significantly associated with increasing tumor thickness according to Breslow. We also observed an increase in the frequency of ulceration of the tumor by 21% in patients with an activating V600 mutation. The frequency of detection of V600 mutations in the BRAF gene in tissues of melanoma was 40%.https://ksma.elpub.ru/jour/article/view/523меланома кожимутацииbrafmelanomamutationsbraf |
| spellingShingle | O. I. Kit D. I. Vodolazhsky E. Yu. Zlatnik I. Yu. Efimova S. S. Kochuev Yu. V. Przhdetsky Association between braf gene mutation status and clinical-morphological features of cutaneous melanoma Кубанский научный медицинский вестник меланома кожи мутации braf melanoma mutations braf |
| title | Association between braf gene mutation status and clinical-morphological features of cutaneous melanoma |
| title_full | Association between braf gene mutation status and clinical-morphological features of cutaneous melanoma |
| title_fullStr | Association between braf gene mutation status and clinical-morphological features of cutaneous melanoma |
| title_full_unstemmed | Association between braf gene mutation status and clinical-morphological features of cutaneous melanoma |
| title_short | Association between braf gene mutation status and clinical-morphological features of cutaneous melanoma |
| title_sort | association between braf gene mutation status and clinical morphological features of cutaneous melanoma |
| topic | меланома кожи мутации braf melanoma mutations braf |
| url | https://ksma.elpub.ru/jour/article/view/523 |
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