Integrated virologic analysis of resistance to nirmatrelvir/ritonavir in individuals across four phase 2/3 clinical studies for the treatment of COVID-19Research in context

Integrated virologic analysis of resistance to nirmatrelvir/ritonavir in individuals across four phase 2/3 clinical studies for the treatment of COVID-19Research in context

Summary: Background: SARS-CoV-2 resistance to nirmatrelvir/ritonavir (NMV/r) surveillance is essential to identify emergence and track treatment-resistance. Methods: This integrative virologic analysis across EPIC (Evaluation of Protease Inhibition of COVID-19) phase 2/3 clinical studies (-High Ris...

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Bibliographic Details
Main Authors: Mary Lynn Baniecki, Shunjie Guan, Devendra K. Rai, Qingyi Yang, Jonathan T. Lee, Li Hao, Edward Weinstein, Craig Hyde, Rhonda D. Cardin, Holly Soares, Jennifer Hammond
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:EBioMedicine
Subjects:
EPIC trials
Nirmatrelvir
COVID-19
Resistance
Mutations
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002634
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