Anemia as a potent marker of in-hospital mortality in patients admitted to the cardiac intensive care unit: Data from the Critical Care Cardiology Trials Network (CCCTN) Registry
Background: Anemia is common in critically ill patients and is associated with poor outcomes. We investigated the prevalence of anemia and its association with in-hospital outcomes among patients admitted to cardiac intensive care units (CICUs) and subgroups within this population. Methods: The Crit...
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Elsevier
2025-07-01
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| Series: | Journal of Intensive Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667100X24001427 |
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| author | Christine Chow Rasheed Durowoju Carlos Alviar Gregory W Barsness Howard A Cooper Lori B Daniels Xuan Ding Shahab Ghafghazi Umesh Gidwani Michael Goldfarb Dustin Hillerson Jason N Katz Paul Marano Jeong-Gun Park Matthew Pierce Scott W Rose Robert O Roswell Sean van Diepen Anjali Wagle Erin A Bohula David D Berg David A Morrow Younghoon Kwon |
| author_facet | Christine Chow Rasheed Durowoju Carlos Alviar Gregory W Barsness Howard A Cooper Lori B Daniels Xuan Ding Shahab Ghafghazi Umesh Gidwani Michael Goldfarb Dustin Hillerson Jason N Katz Paul Marano Jeong-Gun Park Matthew Pierce Scott W Rose Robert O Roswell Sean van Diepen Anjali Wagle Erin A Bohula David D Berg David A Morrow Younghoon Kwon |
| author_sort | Christine Chow |
| collection | DOAJ |
| description | Background: Anemia is common in critically ill patients and is associated with poor outcomes. We investigated the prevalence of anemia and its association with in-hospital outcomes among patients admitted to cardiac intensive care units (CICUs) and subgroups within this population. Methods: The Critical Care Cardiology Trials Network (CCCTN) is a multicenter network of tertiary CICUs in North America. CICU admissions with available baseline hemoglobin (Hgb) between 2017 and 2023 were included in this analysis. Patients were stratified by Hgb levels (Hgb <8 g/dL, 8 g/dL ≤ Hgb <10 g/dL, 10 g/dL ≤ Hgb <12 g/dL, 12 g/dL ≤ Hgb <14 g/dL, and ≥14 g/dL). The ≥14 g/dL group was used for reference. The association of Hgb level and in-hospital mortality was examined by multivariable logistic regression. Results: Among 28,585 patient admissions (median age 67 years, 36.7 % female), the median Hgb was 12.1 g/dL (interquartile range: 10.1–13.9), with 48.3 % of patients who meet criteria for anemia (Hgb <12 g/dL). The adjusted relative odds of in-hospital mortality was highest for patients with Hgb <8 g/dL (1.60, 95 % confidence interval [CI]: 1.35 to 1.89, P < 0.0001), followed by patients with 8 g/dL≤ Hgb <10 g/dL (adjusted relative odds =1.51, 95 % CI: 1.32 to 1.73, P < 0.0001), and patients with Hgb 10 g/dL≤ Hgb<12 g/dL (adjusted relative odds=1.24, 95 % CI: 1.09 to 1.41, P=0.0012). This association was present among those with non-acute coronary syndrome (ACS) cardiogenic shock (n=4255) and those with non-cardiogenic shock ACS (n=7194). Conclusions: Anemia was present in nearly half of patients admitted to CICUs. Lower admission Hgb is independently associated with higher in-hospital mortality in a graded relationship among patients with cardiac critical illness. |
| format | Article |
| id | doaj-art-2f5d4a7266e94ecbb9f5676c3b7df1d1 |
| institution | Matheson Library |
| issn | 2667-100X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Intensive Medicine |
| spelling | doaj-art-2f5d4a7266e94ecbb9f5676c3b7df1d12025-07-03T04:40:30ZengElsevierJournal of Intensive Medicine2667-100X2025-07-0153262268Anemia as a potent marker of in-hospital mortality in patients admitted to the cardiac intensive care unit: Data from the Critical Care Cardiology Trials Network (CCCTN) RegistryChristine Chow0Rasheed Durowoju1Carlos Alviar2Gregory W Barsness3Howard A Cooper4Lori B Daniels5Xuan Ding6Shahab Ghafghazi7Umesh Gidwani8Michael Goldfarb9Dustin Hillerson10Jason N Katz11Paul Marano12Jeong-Gun Park13Matthew Pierce14Scott W Rose15Robert O Roswell16Sean van Diepen17Anjali Wagle18Erin A Bohula19David D Berg20David A Morrow21Younghoon Kwon22Department of Internal Medicine, University of Washington, Seattle, WA, USADivision of Cardiology, University of Washington, Seattle, WA, USADivision of Cardiology, New York University Grossman School of Medicine, New York, NY, USADepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USADepartment of Cardiology, Westchester Medical Center, Valhalla, NY, USADivision of Cardiovascular Medicine, University of California San Diego, La Jolla, CA, USADivision of Cardiology, Johns Hopkins University, Baltimore, MD, USADivision of Cardiovascular Medicine, University of Louisville, Louisville, KY, USADivision of Cardiology, Mount Sinai, New York, NY, USADivision of Cardiology, McGill University, Montreal, Quebec, CanadaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USADivision of Cardiology, New York University Grossman School of Medicine, New York, NY, USADepartment of Cardiology, Cedars Sinai, Los Angeles, CA, USADivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USADepartment of Cardiology, Northwell Health, New York, NY, USADivision of Cardiovascular Medicine, Atrium Health Wake Forest Baptist, Winston-Salem, NC, USADepartment of Cardiology, Northwell Health, New York, NY, USADepartment of Critical Care Medicine and Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, CanadaDivision of Cardiology, Johns Hopkins University, Baltimore, MD, USADivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USADivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USADivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USADivision of Cardiology, University of Washington, Seattle, WA, USA; Corresponding author: Younghoon Kwon, Cardiovascular Medicine, University of Washington, P.O. Box 359748, Seattle 98104, WA, USA.Background: Anemia is common in critically ill patients and is associated with poor outcomes. We investigated the prevalence of anemia and its association with in-hospital outcomes among patients admitted to cardiac intensive care units (CICUs) and subgroups within this population. Methods: The Critical Care Cardiology Trials Network (CCCTN) is a multicenter network of tertiary CICUs in North America. CICU admissions with available baseline hemoglobin (Hgb) between 2017 and 2023 were included in this analysis. Patients were stratified by Hgb levels (Hgb <8 g/dL, 8 g/dL ≤ Hgb <10 g/dL, 10 g/dL ≤ Hgb <12 g/dL, 12 g/dL ≤ Hgb <14 g/dL, and ≥14 g/dL). The ≥14 g/dL group was used for reference. The association of Hgb level and in-hospital mortality was examined by multivariable logistic regression. Results: Among 28,585 patient admissions (median age 67 years, 36.7 % female), the median Hgb was 12.1 g/dL (interquartile range: 10.1–13.9), with 48.3 % of patients who meet criteria for anemia (Hgb <12 g/dL). The adjusted relative odds of in-hospital mortality was highest for patients with Hgb <8 g/dL (1.60, 95 % confidence interval [CI]: 1.35 to 1.89, P < 0.0001), followed by patients with 8 g/dL≤ Hgb <10 g/dL (adjusted relative odds =1.51, 95 % CI: 1.32 to 1.73, P < 0.0001), and patients with Hgb 10 g/dL≤ Hgb<12 g/dL (adjusted relative odds=1.24, 95 % CI: 1.09 to 1.41, P=0.0012). This association was present among those with non-acute coronary syndrome (ACS) cardiogenic shock (n=4255) and those with non-cardiogenic shock ACS (n=7194). Conclusions: Anemia was present in nearly half of patients admitted to CICUs. Lower admission Hgb is independently associated with higher in-hospital mortality in a graded relationship among patients with cardiac critical illness.http://www.sciencedirect.com/science/article/pii/S2667100X24001427AnemiaHemoglobinsIn-hospital mortalityCardiac intensive care unit |
| spellingShingle | Christine Chow Rasheed Durowoju Carlos Alviar Gregory W Barsness Howard A Cooper Lori B Daniels Xuan Ding Shahab Ghafghazi Umesh Gidwani Michael Goldfarb Dustin Hillerson Jason N Katz Paul Marano Jeong-Gun Park Matthew Pierce Scott W Rose Robert O Roswell Sean van Diepen Anjali Wagle Erin A Bohula David D Berg David A Morrow Younghoon Kwon Anemia as a potent marker of in-hospital mortality in patients admitted to the cardiac intensive care unit: Data from the Critical Care Cardiology Trials Network (CCCTN) Registry Journal of Intensive Medicine Anemia Hemoglobins In-hospital mortality Cardiac intensive care unit |
| title | Anemia as a potent marker of in-hospital mortality in patients admitted to the cardiac intensive care unit: Data from the Critical Care Cardiology Trials Network (CCCTN) Registry |
| title_full | Anemia as a potent marker of in-hospital mortality in patients admitted to the cardiac intensive care unit: Data from the Critical Care Cardiology Trials Network (CCCTN) Registry |
| title_fullStr | Anemia as a potent marker of in-hospital mortality in patients admitted to the cardiac intensive care unit: Data from the Critical Care Cardiology Trials Network (CCCTN) Registry |
| title_full_unstemmed | Anemia as a potent marker of in-hospital mortality in patients admitted to the cardiac intensive care unit: Data from the Critical Care Cardiology Trials Network (CCCTN) Registry |
| title_short | Anemia as a potent marker of in-hospital mortality in patients admitted to the cardiac intensive care unit: Data from the Critical Care Cardiology Trials Network (CCCTN) Registry |
| title_sort | anemia as a potent marker of in hospital mortality in patients admitted to the cardiac intensive care unit data from the critical care cardiology trials network ccctn registry |
| topic | Anemia Hemoglobins In-hospital mortality Cardiac intensive care unit |
| url | http://www.sciencedirect.com/science/article/pii/S2667100X24001427 |
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